More than excited to share our latest study from my PhD work published in Science Magazine! We demonstrate that food perception is sufficient to drive adaptational processes in hepatic mitochondria. For more details read the 🧵 and here: science.org/doi/10.1126/sc… Please RT.

Nature research paper: Airway hillocks are injury-resistant reservoirs of unique plastic stem cells go.nature.com/3UqAzcf

💫NEW: Chris Chidley, Sorger & co report a #CRISPR interference/activation #screening platform to systematically interrogate the contribution of nutrient #transporters to support #CancerCell proliferation in environments of variable composition. nature.com/articles/s4155…

HIDDEN no more? 🕵️‍♀️🕵️‍♂️ Up to 1 in 4 patients with kidney failure of uncertain cause actually have a genomically identifiable monogenic aetiology 🤯🤯 So excited to see the KidGen HIDDEN study out in @CJASN! Australian Genomics ANZSN Human Genetics Society of Australasia journals.lww.com/cjasn/abstract…

Likert scale for internists. To what degree do you agree with the following statement: “xxxxxx" I disagree I don't disagree It's not unreasonable It's reasonable I agree

From someone who has studied this field for over 2 decades, I can comfortably say that virtually everything said here is inaccurate. It is incredibly disturbing to me that someone claiming to be a scientist can talk with such authority on something they clearly know nothing about

New favored word! What do you think?

I tweeted about this article earlier today (h/t Dr. Claire McCarthy (she/her) for bringing it to my attention), and I wanted to take a few minutes to talk about why I liked it so much from both a scientific and scientific-communications perspective. 1/

Thrilled to announce AlphaFold 3 which can predict the structures and interactions of nearly all of life’s molecules with state-of-the-art accuracy including proteins, DNA and RNA. Biology is a complex dynamical system so modeling interactions is crucial blog.google/technology/ai/…

I am delighted to share the newest work from the Sternberg Lab, in which we discover RNA-templated gene creation as a mechanism of antiviral immunity. This is a story for anyone who loves molecular biology, and one that repeatedly left us in disbelief. doi.org/10.1101/2024.0…

But no one besides Novartis& Lilly etc. has access to the ligand structure prediction. All the data on ligand binding in the paper is irreproducible and should not have been published. As Reviewer #3 for @nature I recommended taking it out and saving it for promotional material.

With no disrespect to the aurora borealis ... Behold: single human neuron, 5,600 axons connecting to it - new Jeff Lichtman - Google paper in Science.

How to choose good research topic?

Do you really need to spread plasmid libraries on mountains of plates to get uniform growth, or can you just dump them in a flask and call it a day? We make huge plasmid libraries in the de Boer Lab, so we tested whether culture method really matters. 1/ biorxiv.org/content/10.110…

We thought there wasn't much new to learn about the cell cycle. Turns out we were wrong! Our paper (out today nature) identifies a novel alternative cell cycle that regulates differentiation, not cell division. tinyurl.com/4a6yeuke. 1/10

including the chirality of DNA

My document management system is fast and intuitive. You just need to understand the obvious differences between: Final.doc Final_final.doc Final_II.doc True_final.doc Final_undisputed.doc Real_final.doc

Pass it on

“There are not, and will never be, KRAS inhibitors” 👀 PascaLab presents a memorable reviewer comment from her 1st unfunded NIH grant at #AACRPan24. The lesson is that you should not let deflating reviewer comments define the value of your science. Also, persistence!

🚨Thrilled to share our new preprint from my postdoc work in the Rutter Lab! The latest outcome of our close collaboration with Gregory Ducker and Stavros George Drakos labs, where we uncovered something big: mitochondria directly import lactate as fuel in the heart! HHMI U of Utah Dept of Biochemistry