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DSI is a form of synaptic plasticity mediated by endocannabinoids (eCBs). With Linlin Fan, we demonstrated in vivo that place cell activity triggers eCB signals affecting GABAergic inputs; and that cannabinoid receptors modulate place cell tuning. science.org/doi/10.1126/sc…

DSI in vivo!

Loved seeing this project develop on both the basic science and clinical fronts! It was great working with Ryan and having someone with so much hands on clinical experience keep us up to date with current practice in epilepsy.

Excited to share that the O’Hare Lab will open 7/01 in the Department of Pharmacology CU Anschutz Medical Campus! We will use mouse hippocampal place fields as a model system to investigate dendritic mechanisms of learning and memory in vivo. Recruiting at all levels😎 oharelab.org

Very grateful to CureSHANK for supporting a new avenue for the lab! Excited to take on Phelan McDermid syndrome with Joe Buxbaum and April Levin and officially join this amazing community.

Science Salons are fun and stimulating. Experience-dependent inhibitory plasticity in the adult brain Takesian Lab Dr. Bri is on Bluesky 👩🏾‍🔬🧠 Jordan Farrell, Polley Lab, Twitterless Chris Harvey, Takao Hensch, Michela Fagiolini, Sabina Berretta Thanks HarvardBrainScience

Excited to share that the latest Kari Hoffman paper is published in Cell Reports. We describe the dynamics of superficial and deep CA1 pyramidal cells and identified putative groups of inhibitory cells in freely moving, thinking, and sleeping macaques. 1/n

My lab at NYU Center for Neural Science is recruiting trainees at all levels starting in Jan 2025! Our goal is to understand how behavioral variables such as calorie intake and time estimates are computed using molecules inside individual neurons. stephenzhanglab.org

Keith’s paper on parameter optimization for ultrasound neuromodulation is out! Pretty amazing to see the built-in circuit heterogeneity in US responses that enable bidirectional control of behavior without surgery or any genetic tricks.

Very honored to join this group and grateful for the suport!

Check out our new issue: cell.com/neuron/current Cover is for Keith Murphy and colleagues' #NeuroResource on optimized ultrasound neuromodulation for non-invasive control of behavior and physiology in mice. Find it here: cell.com/neuron/fulltex…

I'm usually not into writing reviews, but this was a request was to imagine the future of transcranial ultrasound neuromodulation. Needless to say, I had some inspiration journals.plos.org/plosbiology/ar…

Very grateful for the support from CURE Epilepsy to extend our research on endocannabinoid changes in chronic epilepsy!

Congratulations to Xu Zhang on his Postdoctoral Fellowship from Dravet Syndrome Foundation! Eager to determine the effectiveness of PV cell-optimized ultrasound neuromodulation in a Dravet mouse model. dravetfoundation.org/selective-acti…

What a treat to start the new year with a new paper from the lab, with @azayhara ! Hongyu_Chang and Wenbo Tang found that pupil dynamics in naturally sleeping mice uncover a microstructure of sleep that organizes different types of memory replay: nature.com/articles/s4158…

New paper out in Cell Reports! Led by Susie Yu Feng, we found that chronic epilepsy in mice drives distinct synchronization deficits in hippocampus and MEC, with early changes in HPC and late-onset changes in MEC that align with progressive memory deficits. cell.com/cell-reports/f…

More of Sam's very cool and innovative work from his PhD in the Hoffman lab! Congrats🎉

Nice to see this out. Congrats Shreya Malhotra !