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A suite of experiments that use the gene-editing tool CRISPR–Cas9 to modify human embryos have revealed how the process can make large, unwanted changes to the genome at or near the target site. go.nature.com/2B9Gy0o

Dissipative Control over the Toehold-Mediated DNA Strand Displacement Reaction (Ricci) Francesco Ricci Lab Leonard Prins UNIVERSITÄT LEIPZIG Erica Del Grosso #openaccess thanks to #projektDEAL onlinelibrary.wiley.com/doi/10.1002/an…

Really happy to see my new work in Francesco Ricci Lab finally published in Angewandte Chemie. Thanks to Serena Gentile and to Leonard Prins, @ Ralf Seidel and Patrick Irmisch for the great collaboration! #DNANanotechnology Marie Skłodowska-Curie Actions

Super happy to share my first 1st-author preprint in Francesco Ricci Lab! Check it out👇🏻we combine together #DNA and #enzyme to temporally control DNA-based reaction⏱️ 🧬 Great thanks to Prof. Ralf Seidel and Patrick Irmisch for the collaboration!

Orthogonal Enzyme-Driven Timers for DNA Strand Displacement Reactions Francesco Ricci Lab U Rome Tor Vergata #Enzyme #Strand #DNA #Displacement pubs.acs.org/doi/10.1021/ja…

Finally out in J. Am. Chem. Soc. our work on enzyme-driven "timers" for DNA strand displacement reactions!⏰🧬⏰🧬⏰🧬⏰. Do you want to control *when* a strand displacement reaction starts? Now you can... short thread if interested on how we did that... pubs.acs.org/doi/10.1021/ja… 1/6

I'm thrilled to share that my first 1st-author paper is now online on J. Am. Chem. Soc.!🎉Come read this new strategy to temporally control DNA-based reactions⏱🧬. Thanks Francesco Ricci Lab and Erica Del Grosso for your support and Prof. Seidel and Patrick Irmisch for the great collaboration!💪🏻

⏱️ From this week's covers: Temporal control of DNA strand displacement reactions (SDRs) is achieved using blocker strands and specific enzymes. 🔓 Read the #openaccess article from Juliette Bucci Patrick Irmisch Erica Del Grosso Seidel Francesco Ricci Lab : go.acs.org/2Hn

A quantitative model for the dynamics of target recognition and off-target rejection by the CRISPR-Cas Cascade complex dlvr.it/SdpqRv

Excited to see this outstanding single-molecule study by Marius Rutkauskas finally published in Nature Communications. Super happy to have contributed to this awesome work!! nature.com/articles/s4146…

#CRISPR-Genscheren greifen manchmal auch daneben. Um besser zu verstehen, was dabei passiert, haben Forscher:innen der #UniLeipzig um Dominik J Kauert den Prozess auf Nanoebene sichtbar gemacht: uni-leipzig.de/newsdetail/art… #Nanotechnologie

🥳🥳Just out this week in J. Am. Chem. Soc. !!! pubs.acs.org/doi/10.1021/ja……. In this paper we show how to temporally program pulse output signals in DNA-based strand displacement reactions. Short thread (with gifs) on what we did and how…1/n

🎉Our latest work "Timed Pulses in DNA Strand Displacement Reactions" is now out in J. Am. Chem. Soc. 🧬⏰! Thanks Francesco Ricci Lab and Erica Del Grosso for your constant support 💪🏻! Another great collaboration with Prof. Seidel and Patrick Irmisch 🎊! 🙌🏻Check it out: pubs.acs.org/doi/full/10.10… 📖

Super happy to see this work finally out 🎉🎉 Great thanks to our collaborators in Vilnius!

Enigma of temporal regulation of type III complex activation was solved! We show that retention of the RNA ends provides the molecular memory for maintaining the long activation of the complex for DNA cleavage. Thanks to Ralf Seidel and Patrick Irmisch for great collaboration!