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🎉 Excited to share a big part of my PhD work in Allon Klein Lab that took many, many years and my blood, sweat, and tears! 😅 We ask - What’s the role of cell division in the formation of initial cell types during early development ?🧐 biorxiv.org/content/10.110… 🧵 (1/14)

We are only TWO WEEKS away from the start of the Spatial Biology Summit! It's not too late to register! We are still accepting poster abstracts until the end of this week. More info here: angelolab.com/spatial-biolog… Michael Angelo Bendall Lab

In the current issue of Cell Genomics: Ribosomes varying in rRNA sequence are associated with development and cancer. We developed new methods and found that rRNAs vary predominantly in indels, which form ribosomes of different structures and are visualized in single cells.

I recommend this thoughtful preview article highlighting our recent publication. Thank you Jennifer Gerton Paxton Kostos Anna Galligos for supporting our work! cell.com/cell-genomics/…

Plasticity ⭐️ wow! Tuft cells act as regenerative stem cells in the human intestine | Nature nature.com/articles/s4158…

Tomorrow, together with Lydia Grmai, PhD 🇪🇷🔬🎶, Tyler Huycke and Rachel Zwick we will talk about Zoom Interviews! How to prepare and what to expect.

Now out on Nucleic Acids Res academic.oup.com/nar/advance-ar…

Women lose >90% of their #eggs by their mid-30s, with persistent #DNADamage driving this loss. But why isn’t this damage repaired? Our new work in Current Biology, led by Ninadini Sharma, reveals the causes of high DNA damage in aged oocytes.🧬💥 bit.ly/48e35Ee (1/13)

Can you use ultrasound to identify changes in placental villi that correspond with pathology at delivery? This is the question we sought to address in our newest manuscript. A 🧵 to summarize our findings doi.org/10.1002/jum.16…

Please RT: 📢 Exciting Opportunity! 📢 The Brisa Palikuqi Lab at Yale Med is hiring a Postgrad Research Associate in Stem Cell & Endothelial Cell Biology! Join us in advancing precision medicine through innovative research on regeneration and disease. 🧬 Gain hands-on

Congratulations ⁦Tuomas Tammela⁩ and team on this phenomenal work! 🎉🌟Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis | Nature nature.com/articles/s4158…

Super excited to introduce QUICHE (Quantitative InterCellular Niche Enrichment) - a statistical method that can be used to discover local cellular niches differentially enriched in spatial regions, longitudinal samples, or clinical patient groups :) (1/10) biorxiv.org/content/10.110…

Jolene has done amazing work here. QUICHE is a dramatic improvement over cell neighborhood algos we've used in the past, gets immediately to a common question we ask often: how does spatial structure between two patient groups differ?

1/ What determines the length of gestation? My graduate work out today in Cell revealed that the answer to this mystery may lie in a molecular timer set in motion just days after conception. cell.com/cell/fulltext/…

New study from the lab! All kinds of good and bad and surprising things happen after sleeve gastrectomy bariatric surgery, but happens to the stomach itself? Does it “know” it has been sleeved? How? nature.com/articles/s4146…

I’m super excited to share what I’ve been working on for the last (many) years: a spatial + genomic + transcriptomic characterization of how the breast cancer microenvironment evolves through immunotherapy! (1/x) biorxiv.org/content/10.110…

🧵 (1/8) Today, Benjamin Oberlton and I are excited to share the preprint of our work on: A comprehensive multi-omic study of human gliomas, spanning diagnosis, treatment, and recurrence. We address the longstanding challenge of developing effective therapies for gliomas, which have

Super excited to finally see this published! Our new method to use combinatorial staining and deep learning to push the multiplexing boundaries of spatial proteomics!

Excited to share our latest publication on expanding the multiplexing capability of MIBI-TOF , this can be extended to any technique implementing metal tags for mass spectrometry imaging. Michael Angelo Bendall Lab Patricia Favaro Felix J. Hartmann pubs.acs.org/doi/10.1021/ac…

Super excited to share our new method: Context-dependent Identification of Spatial Motifs (CISM)! 🚀 A two-step approach for uncovering fine-scale intercellular modules associated with human disease states from single-cell spatial data. doi.org/10.1101/2025.0… 🧵 1/n