Announcing Evo 2: The largest publicly available, AI model for biology to date, capable of understanding and designing genetic code across all three domains of life. arcinstitute.org/manuscripts/Ev…

Just published Science Magazine On fixing the NIH 15% cap "The consequences of failing to do so—reduced research capacity, weakened scientific competitiveness, and increased financial strain on institutions—are simply too dire to ignore." science.org/doi/10.1126/sc…

Last night I was honored to receive the 2025 #BreakthroughPrize in the Life Sciences, reflecting the efforts of many students, collaborators, doctors, and patients in labs around the world. I hope this 4-minute excerpt can inspire when science needs public support more than ever.

Organoid experts - can you point me to some papers that show that they can now be used or hypothesize how they could be used in the future as substitutes for animal studies for testing drugs? I'm trying to understand how many of the new FDA proposals are based on actual evidence

I had a similar experience with this N of 1 Why current deep learning sequence models of gene expression struggle to predict counterfactual effects of variants on expression. platform.futurehouse.org/trajectories/9… Also asked for suggestions for improvements platform.futurehouse.org/trajectories/4…

We made a huge poster that illustrates all of the major genome editing tools in one place. You can download a copy for free from the Asimov Press website. press.asimov.com/articles/crisp…

🚫 No dyes. No bleaching. 🔬 Just AI + label-free microscopy = vivid virtually stained images New in Nature Machine Intelligence: A deep learning model that enables robust virtual staining across microscopes, cell types & conditions. #CZBiohubSF Shalin Mehta explains:

Can we use RNA to insert kilobases of DNA into the human genome, opening up a new way to engineer cells or treat disease? Excited to share our latest work turning a retrotransposon (a “jumping gene” with an RNA intermediate) from songbirds into a genome editing tool. 🧵 (1/7)

The NIH has decided that scientists can only submit 6 grants a year. OK. But you need a score that’s < 10% at least to get funded. Meaning, at best, 1 out of 10 grants you submit will have a chance (YMMV of course). 🫠

Have $10M and want to cure some diseases? It costs ~$1B to invent a new medicine…but $10M buys you Project Encore, to see if ANY existing drug might be repurposed for ~100 diseases that have no treatments. Contact me - be a hero for desperate patients! docs.google.com/document/d/1dM…

*Note also no *APCs* at hybrid journals so those journals will be an option if publishing a paywalled article along with associated fees, which is a bummer

🧬 🍀 Gene-edited four-leaf clovers??? There is only one four-leaf clover for every 5,076 three-leaf clovers. So far, we only know that the gene responsible for this rare trait is recessive for the quadruploid plants, and that luck favors warm conditions, approximately

Chemistry writes the story of life. Every cell, every second, it tells it again - powered by molecular design. At the core of this process lies the citric acid cycle, the central hub of metabolism. Here, acetyl-CoA derived from carbohydrates, fats, or proteins enters a precise

We're running a Compound Research Day on Rapid in vivo Iteration in SF in late Feb. In vivo evidence is already arguably the core bottleneck to drug development. This will intensify in a world where we have orders of magnitude more drugs to screen. From safety to efficacy to

Excited to share VIPerturb-seq! New tech from my lab which aims to improve the cost, data quality, and efficiency of single-cell CRISPR screens so that they are accessible to any lab - even at genome-wide scale Preprint and 🧵 (1/): biorxiv.org/content/10.648…

Delighted to share new Arc Institute work from our group on AI-accelerated lab-in-the-loop, in Science Magazine today One of the most remarkable things about biology is that it's digital. DNA, RNA, proteins: these are all sequences, and their function is directly encoded in

Prachee Avasthi genomicsxai.github.io we'll be releasing a lot more over the next few weeks and months through this venue and biorxiv.

🚨 Today in nature, we report GEMINI—a genetically encoded intracellular memory device that writes cellular dynamics into tree-ring-like fluorescent patterns within cytoplasmic protein assemblies.[1/n] nature.com/articles/s4158…

Evo 2 is out in Nature today, showing that genome language models can predict and design across the full complexity of life, from phages to eukaryotes. A few surprises from the project, including how ignoring trillions of nucleotides was key to getting a good model. 🧵

Our paper in nature today 🥳 We tracked 6,438 mice from puberty to death and mapped the genetics of *when* you die, not just whether a gene associates with lifespan. nature.com/articles/s4158… 59 loci. Two decades of data. Thread 👇 #Longevity #Aging #Genetics #Healthspan