Next at #HCMPH symposium, in a meta-analysis, Emily VanSync from Ganda Lab shows that both metformin and type 2 diabetes affect the gut mycobiome, but effect sizes are smaller than previously reported (metformin R2 2%, T2D 1.2%).

Delphine Tripp from Tami Lieberman lab discusses prophage dynamics in C. acnes genomes at #HCMPH. Prophage carriage is relatively rare, and the signal is phylogenetically inconsistent.

Next, Corinne Maurice talks about how spontaneous prophage induction in the healthy human gut is extremely common pubmed.ncbi.nlm.nih.gov/36798434/. A cool example of how applying new software tools to an old metagenomic dataset can tell us new things!

Next, PhD student Hayley Gause from #UCSF discusses using RNA-seq to compare E. faecalis and C. albicans co-culture in vitro and in vivo. Co-culture influenced candida's iron metabolism, transcription factors, and parasexual cycle. #HCMPH.

Next at #HCMPH, @dmap02 from #NIH uses genomics to study Candida auris transmission. She shows it is often transmitted asymptomatically on the skin, along with multiple other ESKAPE pathogens.

Next at #HCMPH: Nikos Kyrpides on how 3 teams' (with Rob Finn Segata Lab ) efforts catalogued over 200,000 human gut reference genomes, and how checkV (pubmed.ncbi.nlm.nih.gov/33349699/) was developed to QC the 3.5 million viral contigs assembled from this dataset.

Next at #hcmph, Schirmer Lab shows how oral bacteria became enriched in the gut microbiomes of children with severe UC in the PROTECT study pubmed.ncbi.nlm.nih.gov/30308161/. In Veilonella, this relates to nitrate respiration.

Next at #hcmph, Rachel J Dutton sequences camembert cheese to model cross-feeding in microbial communities and shows that bacteria and fungi work together to digest the amino acids in casein. Fungi also help to alleviate bacterial iron uptake defects.

Last at #HCMPH, Joseph Petrosino on child gut fungal profiles in TEDDY (early T1D) cohort. Child fungal profiles are quite different from adults, sometimes have unique country-specific features, & a few species were linked to future asthma/celiac.

IID’s Wendy Garrett presented the welcoming remarks at the Harvard Chan Microbiome in Public Health Center (Harvard Chan Microbiome in Public Health Center) fifth annual symposium.

In a new Nature Reviews Cancer article, team OPTIMISTICC’s Geniver el Tekle & Wendy Garrett of Garrett Lab Harvard T.H. Chan School of Public Health explore the roles of bacteria in gastrointestinal tract malignancies and cancers of the lung, breast and prostate 🔽 nature.com/articles/s4156…

We are extremely pleased to announce that Macarron has officially been published. Please check out the paper here: embopress.org/doi/full/10.10… and the software here: huttenhower.sph.harvard.edu/macarron/

Come join us at the HCMPH symposium on May 13th! The deadline for poster abstracts has been extended to April 22nd!

We are still accepting abstracts for our upcoming Symposium on May 13th. TWO posters will be selected to give short talks!

Less than one week left to sign up for our class on microbial multi-omics! Check it out below: evomics.org/2024-microbial…

Need help planning your microbiome study, or processing, analyzing, or visualizing your data? The Harvard Chan Microbiome Analysis Core can help with all stages of a project! hcmph.sph.harvard.edu/hcmac/services/.

Wouldn't it be fabulous if you could perform a microbiome research study without worrying about sample collection, aliquoting, and storage? The Harvard Chan Microbiome Collection Core can help! hcmph.sph.harvard.edu/hcmcc/services/.

NEXT Monday (May 13) join us at #HCMPH2024* Francesco Asnicar will give a talk: Human gut microbiome as a tool in oncology *virtual registration is FREE hcmph.sph.harvard.edu/hcmph-symposiu… Harvard Chan Microbiome in Public Health Center hutlab

The largest and most diverse study yet of the gut microbiome and type 2 diabetes, led by the Curtis Huttenhower and Daniel Wang labs, reveals that the presence of specific viruses and bacterial variants in the microbiome corresponds with #T2D risk. broad.io/T2D-gut

I'm excited to announce two upcoming HCMPH events. Our annual symposium (May 19th) has a fantastic line of talks lined up around the theme "the #microbiome in food systems." We're also hosting a microbiome course June 2-6. (huttenhower.sph.harvard.edu/biobakery2025/)