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Two kids with HSV-1 encephalitis were found by Casanova Lab to have rare mutations that indirectly allowed the virus to enter their brain cells, demonstrating how protein deficiencies and mutations can facilitate brain inflammation via viral infection. nature.com/articles/s4158…

Columbia University Announces New $400 Million Gift from Roy and Diana Vagelos. Learn more: columbiamed.link/4ecuoRt

Scientists should get paid for thinking time nature #PhD #PhDlife #academics #AcademicChatter #AcademicTwitter #Postdocs #Research #Science

Thank you Kyle! I had an awesome time visiting. Amazing research happening at Purdue Biochemistry Purdue Biochemistry and Kyle’s lab Kyle Cottrell!!

About 10% of people who develop severe Covid have autoantibodies to Type 1 interferon, which doesn't get diagnosed. Now there's a simple assay. It's also relevant for other life-threatening viral illnesses, and these Abs exist in ~100 million people worldwide.

An important study by F. Eun-Hyung Lee's team shows that long lived plasma cells (the source of long-term circulating antibodies) fail to establish after mRNA vaccination (even combined with SARS-CoV-2 infection). 🧵 (1/) nature.com/articles/s4159…

Wow!! One of the best meetings ever!! Thank you IdoAmitLab and Jonathan Kipnis 💔🎗️ 👍👍👍

For the Molecular Cell RNA focus issue, I put together a piece featuring the voices of Li Yang, Igor Ulitsky 💔, Wendy Gilbert, Chengqi Yi, ule_lab, and @maiwench on the challenges of investigating RNA function: authors.elsevier.com/a/1jt7A3vVUPRm…

Nobel Prize in Physiology or Medicine: Biology Nobel Prize in Chemistry: Biology Nobel Prize in Physics: Sounds like Biology #NobelPrize

Thrilled to share our review article, 'Mechanisms Suppressing Noncoding Translation,' co-authored w/ Jordan Kesner. Grateful to Trends Cell Biology editors Bryan Harada (Bryan Harada) and Ilaria Carnevale (Ilaria Carnevale) for their invitation and support! authors.elsevier.com/a/1jzmb3QxxSux…

1. Hi #RNA friends, just in time for the holidays I am excited to share the latest pre-print from my group. We solved the structure of a mysterious viral RNA that resists degradation by host nucleases. A short 🧵 & link below – please also check out the full video! #lovevirology

Hallmarks of brain aging from a comprehensive single-cell sequencing of 1.2 million cells Specific cell-type pattern, role of immune response, inflammation, and a potential hypothalamus (near 3rd ventricle) hot spot for aging nature.com/articles/s4158… nature Allen Institute

"[My adviser] told me that instead of focusing on finding a dream job, I should think about what I am good at and what makes me happy at least 80% of the time. This advice surprised me at first, but it ended up being exactly what I needed to hear." scim.ag/7aJ

Postdoc position available. Please repost🙏

Exciting results! Using AID-Degron system, Dr. Yimeng Zhu found that Ku suppresses RNA-mediated innate immunity to accommodate Alu-expansion in primates - solving the misery of Ku essentiality in human cells! Thank@chaolinzhang⁩ biorxiv.org/content/10.110…

The truth is that the scientific process is horribly inefficient and wasteful. But the solution is NOT cutting funds and it’s NOT top down guidance of what should be studied. Instead, we should revolutionize how we publish and improve peer review.

NIH cuts are hitting young scientists the hardest. By David Baker. timmermanreport.com/2025/03/david-…

My lab is recruiting a postdoc to study innate immunity to RNA viruses at the Harvard School of Public Health! academicpositions.harvard.edu/postings/14810

PACT and PKR, the most amazing duo! Congratulations!