🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Just posted bioRxiv manuscript reporting neutralizing antibody evasion and #CryoEM atomic-level structure of #COVID19 #OmicronVariant spike protein-ACE2 interface (PDB 7T9L), suggesting rationale for increased transmissibility of #Omicron biorxiv.org/content/10.110…

Interested in #teamtomo & how to strategize for #montage & other aspects of #cryoET data collection? Try #TomoGrapher at github.com/wright-cemrc-p… written by Matt Larson & JYangE UW–Madison Biochem. Read about developments in #cryoCLEM #cryoFIB #cryoET at biorxiv.org/cgi/content/sh…

Delighted that our work with Jamie Williamson and Jessica Rabuck-Gibbons on characterizing ribosome assembly heterogeneity is out in Structure. Raw data that gave rise to 42 distinct intermediates is freely available on EMDB - EMPIAR @EBI. More below. 1/12

Really cool!

From Alexis Rohou (Alexis Rohou) of Genentech and colleagues, a video article on how to configure gP2S, a web application for the tracking of cryoEM experiments. Watch the video on JoVE: hubs.ly/Q013j9xW0

Attend next week's International Steenbock Lectures in Biochemistry to hear from Sjors Scheres @MRC_LMB on developments in #cryoEM and what cryo-EM can tell us about #amyloid filaments in the brain. Livestream: go.wisc.edu/bio_colloq Sjors Scheres Tim Grant

Kicking off the 2023 ⁦Cold Spring Harbor Laboratory⁩ #CryoEM course! Participants have braved flight delays, train fires, and long immigration lines to be here, looking forward to the next 2 weeks!

Our latest publication reports the cryo-EM structures of the human Polα-Primase DNA elongation complexes - rdcu.be/c96yY A Lim lab X Tahirov lab collaboration led by Qixiang He 贺琦翔 and Andrey. Thank you, Sara Osman & NatureStructMolBiol, for working with us! Please RT to share! 1/4

I love it when proteins move a lot! In our just published structure of DNA replication restart proteins PriA/B + replication fork (nature.com/articles/s4146…) we see one domain swing almost 90° upon DNA binding, turns out this is important. Awesome collaboration with Keck Lab.

We're #hiring! Join our department as a Professor of Biochemistry (open rank). Visit go.wisc.edu/biochem-facult… for more info and to apply. #FacultyJobs #PhDJobs #Biochemistry #TenureTrack

An Oct. 2-5 workshop Wisconsin Institute for Discovery will bring together #MassSpec and #CryoEM scientists to explore the possibilities and challenges of these novel techniques. Registration is open. For more info, visit coonlabs.com/ms_23/. Coon Lab Elizabeth Wright Tim Grant

Congrats to the IPiB students who received poster awards at the IPiB Retreat! Roma Broadberry (Grant Lab) Jess Davidson (Simcox Lab) Kyle Flickinger (Cantor Lab) Evelyn Okal (Raman Lab) Phoenix Shepherd (Kirchdoerfer Lab) More photos from the day: flic.kr/s/aHBqjAVhZi

Congrats to those from our Morgridge community, Roma Broadberry from the Tim Grant and Kyle Flickinger from the Jason R. Cantor Lab! 👏 #FearlessScience #RisingSparks

Congratulations Roma Broadberry! Very proud

nature.com/articles/d4158… I feel there can't be many people who have a quote containing colorful language in a journal?

Great to have Pete in the lab!

1/6: #CryoEM Exhausted with fighting the air-water interface (AWI) problem during sample grid plunge freezing? We may have an easy solution for you! Read our latest preprint on how we use LEA proteins as AWI sample protectants for challenging samples: biorxiv.org/content/10.110…

Congrats to Tommy Anderson on his first author publication from our lab detailing the first structure of a polymerase complex from an alphacoronavirus, PEDV! Also a big shoutout to Josh Coon who helped with the native MS analysis! academic.oup.com/nar/advance-ar…

Learning how to process data using cisTEM and Relion at the cryoEM CSHL Courses ! Tim Grant

Making cryo-EM grids by flying particles through a native mass-spec is pretty cool, but can it be cooler? Yes - by adding a LASER! Particles damaged by the process can be fixed by adding a thin layer of ice then briefly hitting the grid with a laser! tinyurl.com/49aurm35