Matthieu Gagnon (@gagnon_lab) 's Twitter Profile
Matthieu Gagnon

@gagnon_lab

Associate Professor, Microbiology & Immunology/Biochemistry & Molecular Biology, Structural studies of translation machinery, Ribosome, Antibiotics, Cryo-EM

ID: 1687144263535009810

calendar_today03-08-2023 16:52:09

113 Tweet

118 Followers

111 Following

Sergey Melnikov (@sergeyvmelniko1) 's Twitter Profile Photo

In this review, we explore the potential impact of ribosome-targeting antibiotics on ribosome dormancy, a process that protects ribosomes from degradation in metabolically inactive cells: frontiersin.org/journals/micro…

Richard H. Ebright (@r_h_ebright) 's Twitter Profile Photo

Structural basis of RfaH-dependent transcription-translation coupling termination (Collaboration between our laboratory and laboratories of Gregor Blaha and Chengyuan Wang.) nature.com/articles/s4159…

The Ban Lab (@the_ban_lab) 's Twitter Profile Photo

In our new study we reveal how NAC coordinates and regulates successive co-translational nascent chain ⛓️ processing on the mammalian ribosome out today in nature rdcu.be/dRAQY collab with Deuerling Lab Shu-ou Shan Caltech Swiss National Science Foundation European Research Council (ERC) ETH Zurich

The Welch Foundation (@welchfoundation) 's Twitter Profile Photo

Principal Investigator Matthieu Gagnon and researchers at UTMB Health use cryogenic-electron microscopy to elucidate the mechanism of GDP dissociation from RF3 catalyzed by the Escherichia coli 70S-TC. buff.ly/4dxEqwm

Sergej Djuranovic (@djuranoviclab) 's Twitter Profile Photo

The beauty of protein synthesis and its main players - ribosomes, mRNA and protein, seen in artistic view at CSHL. Once again at CSHL Meetings Translational control and protein synthesis.

The beauty of protein synthesis and its main players - ribosomes, mRNA and protein, seen in artistic view at CSHL.
Once again at <a href="/cshlmeetings/">CSHL Meetings</a> Translational control and protein synthesis.
Suzuki Lab. (@suzukirnalab) 's Twitter Profile Photo

We're excited to announce the publication of our latest study on the identification of a novel tRNA modification, 2-aminovaleramididine (ava2C), and its molecular basis on decoding. Congratulations and thanks to our wonderful collaborators! rdcu.be/dUr0l

Sergej Djuranovic (@djuranoviclab) 's Twitter Profile Photo

Btw for solving E.coli or other bacterial ribosomes structures by cryoEM as well as to use wt or mutated E.coli ribosomes for assays you don't need more than 50mL cultures. RAPPL isolates enough of them for cryoEM, in vitro studies or even ribosome complexes with nascent

Btw for solving E.coli or other bacterial ribosomes structures by cryoEM as well as to use wt or mutated E.coli ribosomes for assays you don't need more than 50mL cultures. RAPPL isolates enough of them for cryoEM, in vitro studies or even ribosome complexes with nascent
Sergey Melnikov (@sergeyvmelniko1) 's Twitter Profile Photo

This new preprint from the Cate lab provides insights into the fate of ribosomes in stationary archaea. Using an organism adapted to 95°C, they identify a protein called Dri, which appears to act as an archaea-specific ribosome hibernation factor: biorxiv.org/content/10.110…

This new preprint from the Cate lab provides insights into the fate of ribosomes in stationary archaea. Using an organism adapted to 95°C, they identify a protein called Dri, which appears to act as an archaea-specific ribosome hibernation factor: biorxiv.org/content/10.110…
Sergey Melnikov (@sergeyvmelniko1) 's Twitter Profile Photo

Actinobacteria appear to possess a species-specific ribosome hibernation factor, found in Mycobacteria, that binds to the nascent tunnel of dormant ribosomes. More in this exciting study by Ojha and Agrawal lab: biorxiv.org/content/10.110…

Actinobacteria appear to possess a species-specific ribosome hibernation factor, found in Mycobacteria, that binds to the nascent tunnel of dormant ribosomes. More in this exciting study by Ojha and Agrawal lab: biorxiv.org/content/10.110…
AlbertW_lab (@albertw_lab) 's Twitter Profile Photo

We are excited to share our latest work on the cooperation between RNA polymerase and the ribosome in bacteria: science.org/doi/10.1126/sc… The work was supported by IGBMC, Inserm, CNRS 🌍, -, @ERC_research, IMCBio Graduate School, and Instruct-ERIC. 1/7

Ruben Gonzalez (@rubenlgonzalez) 's Twitter Profile Photo

Our latest work is out in nature today! Using smFRET, we directly visualized recruitment of the eIF4F complex to the 5' cap of eukaryotic mRNAs and formation of an activated mRNA. Our findings reveal new and surprising roles for each eIF4F component. 1/3 nature.com/articles/s4158…

Our latest work is out in <a href="/Nature/">nature</a> today! Using smFRET, we directly visualized recruitment of the eIF4F complex to the 5' cap of eukaryotic mRNAs and formation of an activated mRNA. Our findings reveal new and surprising roles for each eIF4F component. 1/3 nature.com/articles/s4158…
Stefan Pfeffer (@pfeffercryolab) 's Twitter Profile Photo

Out just now at Nature Communications: using cryo-EM and cryo-electron tomography, we provide evidence that structurally heterogeneous ribosomes can cooperate in protein synthesis in bacterial cells: nature.com/articles/s4146…

nature (@nature) 's Twitter Profile Photo

Nature research paper: A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome go.nature.com/3FJLuu0

WilsonLab (@wilsonlab2) 's Twitter Profile Photo

In our newly published study we show that the proline-rich antimicrobial peptide (PrAMP) Bac5 has a distinct mode of interaction with the ribosome compared to other PrAMPs…academic.oup.com/nar/article/53…

Matthieu Gagnon (@gagnon_lab) 's Twitter Profile Photo

1 of 2: Ever wondered how newly synthesized proteins are released from the ribosome? An exciting collaboration between the Polikanov and Matthieu Gagnon groups elucidates this conundrum.

Matthieu Gagnon (@gagnon_lab) 's Twitter Profile Photo

2 of 2: Instead of activating a water molecule for hydrolysis, as previously thought, release factors induce a structural change in the transfer RNA, enabling its own 2’OH group to attack and break the bond, a universal process in all organisms. science.org/doi/10.1126/sc…

WilsonLab (@wilsonlab2) 's Twitter Profile Photo

Preprint from our collaboration with the labs of Gerry Wright and Shura Mankin Mankin_Vazquez_Lab identifying the first translation inhibitor binding to the E-site of the bacterial ribosome… researchsquare.com/article/rs-692…

Ahmad Jomaa (@jomaa_lab) 's Twitter Profile Photo

Check out our new preprint on the discovery of a molecular switch in NAC that mediates nascent chain sorting on the ribosome and prevents mitochondrial protein mistargeting by SRP. A great collaboration with the Shan Lab Caltech and the Qi Lab UVA: biorxiv.org/content/10.110…