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The first crystal structure of an alternative DNA shape from the insulin gene has been revealed by UCL, UK. The study shows that different sequence variants in the gene form distinct DNA structures, impacting insulin regulation. More in Nature Communications: nature.com/articles/s4146….

A new method to target GTPase enzymes linked to cancer & neurodegenerative diseases has been discovered UC San Francisco, USA. Researchers tested K-Ras-targeting drugs on other mutated GTPases, revealing new drug-binding sites. Findings in @CellPressNewsl: bit.ly/3YjGl2j.

New strains of Acinetobacter baumannii, a top priority pathogen identified by World Health Organization (WHO) due to its role in multi-drug-resistant infections, have been engineered by University of Liverpool, UK, facilitating the development of medicines targeting this bacteria. More here: journals.asm.org/doi/10.1128/aa….

A kidney organoid-based proximal tubule-on-chip (OPTECs-on-Chip) that closely mimics in vivo renal physiology has been developed by a team Kyoto University, Japan. More in iScience journal: bit.ly/3NmkGAw

The role of pharmacists in deprescribing proton pump inhibitors is the research focus of Syed Arman Rabbani, associate professor RAKMHSU, UAE🇦🇪, reflecting a commitment to optimising drug therapy and enhancing patient care.

MED6-189, a compound inspired by marine sponge extracts, has demonstrated effectiveness against drug-sensitive & drug-resistant  Plasmodium falciparum strains  in vitro & in humanised mouse models, report UC Riverside & Yale School of Medicine, USA, in Science Magazine science.org/doi/10.1126/sc…

Monoclonal antibodies against Acinetobacter baumannii, a multi-resistant bacteria associated with hospital-acquired infections, have been developed using genetically engineered mice by researchers at Cambridge University, UK. More in Nature Communications: nature.com/articles/s4146….

NMR and X-ray scattering methods were used by researchers from 千葉大学広報, Japan to examine how mixing sequence impacts structure & efficacy of small interfering RNA (siRNA)-loaded lipid nanoparticles . More in @JControlRel: doi.org/10.1016/j.jcon…

An organic-solvent-free method for peptide encapsulation in poly(lactic-co-glycolic acid) microspheres has been found by researchers from University of Michigan, USA, to offer sustained in vitro peptide release for over 56 days. Read more in Nature Communications: doi.org/10.1016/j.jcon…

Optimising magnesium stearate content & low-shear mixing improves aerosolisation in carrier-based dry powder inhalers, establishing a correlation between rheological parameters & fine particle fraction. More in the International Journal of Pharmaceutics: sciencedirect.com/science/articl…

A personalised dietary programme can significantly improve aspects of cardiometabolic health compared to standard dietary advice, according to a randomised clinical trial conducted by the King's College London, UK. More in Nature Medicine: nature.com/articles/s4159…

Personalised brain circuit scores reveal six biotypes in depression and anxiety according to a study by Stanford Medicine, USA. These biotypes predict symptoms, behaviour & treatment response, paving the way for precision psychiatry. More in Nature Medicine: nature.com/articles/s4159…

FIP’s Pediatric Formulations Focus Group study on paediatric compounding was featured in Hospital Pharmacy Europe last week: bit.ly/3WsQSHf. Lead author & focus group chair Hala Fadda discusses off-label prescribing in paediatrics, & the study’s findings & recommendations.

A blood-first assay screening trial found entrectinib equally effective in advanced/metastatic non-small cell lung cancer patients diagnosed by liquid biopsy or tissue testing, achieving an 81.5% response rate. More in Nature Medicine: nature.com/articles/s4159…

Giovanni Pauletti, Pharmaceutical Science at FIP chair, shares his vision for strengthening pharmaceutical sciences & empowering the next generation of scientists to drive innovation.📖Read the full interview in this month’s International Pharmacy Journal (IPJ): fip.org/publications?i….

"Pharmacy practice research is the key to advancing global health," says Victoria Cardenas, Chair of the FIP Pharmacy Practice Research SIG. Read the full interview in the BPS newsletter – available in the FIP Library: fip.org/publications?p….

In this perspective from Maria Laura Bolognesi and team, the UN Sustainable development goals are placed in the context of medicinal chemistry and outlines how we can “turn words into actions”. pubs.acs.org/doi/10.1021/ac…

This year, we celebrate 100 years of pharmaceutical sciences at FIP! Learn more about the formation of the Board of Pharmaceutical Sciences in 1925 in the Pharmaceutical Science Newsletter: fip.org/publications?p….