The latest #CRISPR-​based genome editing systems are safer for patients who will soon benefit from gene therapies, as Eric Aird explains in the latest #ZukunftsBlog ETH Zurich D-BIOL @ ETH Zurich #GenomeEditing ethz.ch/en/news-and-ev…

The Jacob Corn reports on Recursive Editing, a way to drive high levels of #CRISPR-mediated precise genomic modification without manipulating cell factors or state. An accompanying easy-to-use software designs experiments to optimize target selection. biol.ethz.ch/en/news-and-ev…

WORLD CRISPR DAY is back! We'd love for you to join us at Synthego's amazing, virtual, free scientific symposium that brings together genome engineering scientists, clinicians, and thought leaders from around the world! Please register for free at worldcrisprday.com

Today in @bioRxiv, we describe Click Editors (CEs) which combine DNA-dependent DNA polymerases, HUH endonucleases and RNA-programmable nickases for versatile genome editing without double-strand breaks 🧬. A study co-led with Connor Tou. A 🧵 (1/14): biorxiv.org/content/10.110…

Amazing postdoc Eric Aird asked how #CRISPR gRNAs & interferon regulate innate #immunity. He found a wild partnership that balances appropriate response w/ cell death. SP100 builds filaments that kill cells, and SP110 breaks them to keep things in line. biorxiv.org/content/10.110… 🧵