Effrosyni Alexandrou
@effrosynia
PhD student at the UCL School of Pharmacy.
Nucleic acids, Crystallography, Biophysics.
ID: 1318991220362838019
21-10-2020 19:03:21
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66 Followers
165 Following
The postdoc in our team is doing the one million step challenge for Diabetes UK Chris Morris Follow their progress and donate here: step.diabetes.org.uk/fundraising/di…
It is not too late to register for Dr Zoë Waller's talk and Q&A on the changing shape of #DNA in #diabetes this Thursday, the 17th November. Find details of how to get in touch below! Diabetes UK
We have a preprint out looking at DNA i-motif structure & function in the insulin gene. Including an intramolecular crystal structure of an i-motif🧬 Team including Chris Morris Shozeb Haider Chris Waudby Effrosyni Alexandrou UCL School of Pharmacy Diabetes UK biorxiv.org/content/10.110…
And another edition of our Synchrotron Radiation School is over. We had a week full of lectures and experiments between University of Oxford and Diamond Light Source. Thank you to all our speakers and to the delegates who joined us from all over the🌍What a fantastic week in #science!
Our paper about solving the crystallographic phase problem by long-wavelength crystallography is out! A great review on what's feasible on Beamline I23 - Diamond Light Source Diamond MX Beamlines Diamond Light Source Research Complex at Harwell Rosalind Franklin Institute STRUBIOxford University of Sussex Imperial College London nature.com/articles/s4200…
Another great collaboration with Dr Zoë Waller in developing a novel method for predicting DNA i-Motifs Via Machine Learning Bibo Yang Haopeng Yu John Innes Centre UCL biorxiv.org/content/10.110…
Happy new year! QN-302 is a beautiful molecule and it was a pleasure to work with Prof Stephen Neidle on this. The beautiful artwork is by the first author Effrosyni Alexandrou Video explainer to follow!
More artwork and a video explainer in plain English by Effrosyni is now on YouTube ❤️ youtu.be/prpzmbysIbw?si… Effrosyni Alexandrou OBC UCL School of Pharmacy
Congratulations to Wenqian on passing her PhD upgrade. Thanks to stephen hilton Rachael Dickman for examining
Are you wondering how Alphafold3 actually copes with nucleic acids? Shozeb Haider has done some testing to see exactly how much it can predict, with known examples, shown as a thread here. Essential reading for those interested in DNA and RNA. UCL School of Pharmacy UCL Faculty of Life Sciences
Our latest work on structure and dynamics of the RNA quadruplex from the non-coding region of the Pseudorabies virus in complex with ND11 naphtalenediimide. UCL School of Pharmacy Paper: doi.org/10.1016/j.bioc…
Our paper describing structural details of the DNA structures in the insulin linked polymorphic region is out. Team effort from UCL School of Pharmacy. Nature Communications UCL School of Pharmacy UCL Faculty of Life Sciences Shozeb Haider Chris Morris Chris Waudby Effrosyni Alexandrou nature.com/articles/s4146…
Shozeb Haider has made a lovely video to show the structure in three dimensions
In our latest multidisciplinary work, we report on the first crystal structure of an intramolecular i-motif DNA from the insulin-linked polymorphic region. Published in Nature Communications nature.com/articles/s4146…
Dr Zoë Waller Chris Waudby Chris Morris Gary Parkinson Effrosyni Alexandrou UCL School of Pharmacy Here is a structural video
The first crystal structure of an alternative DNA shape - i-motif DNA, an interlocking structure that differs from the double helix - from the insulin gene has been revealed by UCL scientists led by Dr Zoë Waller UCL School of Pharmacy ucl.ac.uk/news/2024/sep/…
New Paper from I23 in Nature Communications doi.org/10.1038/s41467… (pdbe.org/8AYG)