Multiple Nf1 Schwann cell populations reprogram the plexiform neurofibroma tumor microenvironment. New in JCI insight w/ Leah Kershner, Kwangmin Cho, Jianqiang Wu, Dr. Xiyuan Zhang , Melissa Perrino, Nathan Salomonis, Jack Shern, & Nancy Ratner insight.jci.org/articles/view/…

Single-cell sequencing reveals activation of core transcription factors in PRC2-deficient malignant peripheral nerve sheath tumor dlvr.it/SZ5SdS

I had the opportunity to meet some brilliant young students during the #AACR23 Undergraduate Poster Competition. I am proud to support the AACR's science education initiatives by sponsoring the prizes that recognize their outstanding research.

So proud of my postbac Hilda Jafarah for winning the #AACR2023 Undergraduate Poster Competition. Way to go!! @NCI_CCR_PedOnc @NCIResearchCtr Jack Shern

Come by my poster tomorrow morning to learn about the first spontaneously metastatic xenograft model of #rhabdomyosarcoma #aacr23 Dr. Marielle Yohe AACR @NCI_CCR_PedOnc

Huge congratulations to our own @bega_murray on her Scholar-in-Training award-winning work. If you are attending #AACR2023, please plan to stop by her poster on Tuesday. We are ready to witness our youngest doctor from the Jack Shern lab🌟

Dear all - I just started my lab at Mount Sinai NY! I will be hiring at all levels to carry out my NIH R01 funded research on the epigenetic regulation of cell identity and memory, and the translation of which to treat liver diseases. Please spread the word! 🐭👩‍🔬🙏 1/2

Always grateful for the opportunity made possible by Children's Tumor Fdn to share our research from the Jack Shern lab on NF1 tumor single-cell atlas. Together with entire NF1 clinical team @NCI_CCR_PedOnc, we fight to #endNF ❤️

感谢您的付出和关注！Thank you❤️

And congratulations on winning the poster competition! Well deserved Namrata GR Raut (she/her)

Exciting talk by Sara Gosline Gosline from PNNL on using model systems data to enable AI assisted drug response predictions … Children's Tumor Fdn #EndNF #NFcon24 Also.. cool enough to wear a party hat to celebrate a friends birthday 🥳 well done Dr Gosline !

How many times do we think this figure has been shown during this meeting ? It’s a favorite ! Here it is again by Dr Xiyuan Zhang from @NCI_CCR_PedOnc - the scientist responsible for its design in her 2020 review article on PRC2 dysregulation.

NCI scientists have mapped key regulatory changes that occur when a common #neuroblastoma therapy, retinoic acid, drives tumor cells to develop into neurons, thereby curbing their growth. spr.ly/6010lTCwE @NCIResearchCtr

ASAP1 and ARF1 regulate myogenic differentiation in #rhabdomyosarcoma by modulating TAZ activity. bit.ly/3UQJiWe #sarcoma Katie Hebron, Ph.D. Jack Shern Dr. Marielle Yohe National Cancer Institute Vanderbilt University

In a phase 2 trial of adults with #neurofibromatosis type 1 and inoperable plexiform neurofibromas, the #MEK inhibitor #selumetinib shows an ORR of 63.6% and improved patient outcomes with additional biopsy data on drug activity. nature.com/articles/s4159…

With NIH cuts making research funding harder to secure, CRI is stepping up! We’re committing $2.5M to support 10 additional postdocs so that promising #CancerResearch doesn’t get left behind. Learn more: bit.ly/4iEQNsJ

GPC2-Targeted CAR T Cells Engineered with NFAT-Inducible Membrane-Tethered IL15/IL21 Exhibit Enhanced Activity against Neuroblastoma doi.org/10.1158/2326-6… Reona Okada MD PhD Constanza Rodriguez Dr. Xiyuan Zhang Taisuke Kondo, D.V.M., Ph.D. National Cancer Institute @NCI_CCR_PedOnc