Inspired to get creative with my poster for @ictmc2024 this week! I shared my work on bayesian generalised linear mixed models to optimise treatment dosage in early phase trials using Patient-reported Outcomes. #ICTMC2024 #clinicaltrials

Excited to share our paper in Nature Biotechnology, work led by Shaobo Yang and Michal Sheffer in my lab in collaboration with Jiahe Li University of Michigan nature.com/articles/s4158… #NK #immunotherapy #bacteria Dana-Farber News Dana-Farber #RomeeLab

nBregs & early-life microbiota Newborn regulatory B cells (nBreg) autocrinally regulate IgM via IL-10. mAbs from intestinal nBregs react against diverse bacteria, highlighting role of nBreg Abs in microbial diversity & early-life microbiota communities cell.com/cell-host-micr…

ScRNA-seq defines pan-cancer atlas of tumor-infiltrating B cell subsets Preview Cancer Cell cell.com/cancer-cell/fu… cell.com/cancer-cell/fu… doi.org/10.1016/j.cell… science.org/doi/10.1126/sc…

Second round of review when the reviewers reject the authors' response-to-reviewers arguments

NK-cell-specific Trp53 disruption in mice leads to the development of NK-cell lymphomas after long latency, and highlights CXCL16, KLRG1, and MYC as potential therapeutic targets in ENKTCL nature.com/articles/s4146…

Emails from journal editors be like:

Dietary nucleic acids expand small intestine IELs via MAVS/STING/TBK1 induced IL-15, with IEL TGF-β1 promoting activation of gut CD103+ DC that induce antigen-specific Treg cells & oral tolerance nature.com/articles/s4146…

New Cell resource: Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging cell.com/cell/fulltext/… Impressive dataset of aging associated transcriptomics alterations across multiple tissues that identifies

Comprehensive snapshots of NK cells functions, signaling, molecular mechanisms and clinical utilization Youssef Jounaidi Signal Transduction and Targeted Therapy (STTT) nature.com/articles/s4139…

Disseminated tumor seeding cells utilize the PGE2-EP2/EP4 axis to induce NK cell dysfunction and immune escape following organ colonization Cell Reports Jan Böttcher @AMPedde cell.com/cell-reports/f…

Excited to share our new paper in Journal of Experimental Medicine 🎉 We show that NK cells use autocrine TGF-β1 signalling to establish tissue residency, form a highly cytotoxic subset, and protect the tissue against viral persistence. rupress.org/jem/article/22…

Online Now: Contrasting cytotoxic and regulatory T cell responses underlying distinct clinical outcomes to anti-PD-1 plus lenvatinib therapy in cancer dlvr.it/THhBsp

New findings cast light on the role of understudied DN3 #MemoryBcells in cancer, and shows these cells correlate with progression and poor clinical outcomes in #HNSCC and melanoma. Tullia Bruno, PhD Dr.YayaTheScientist Pitt Micro/Immuno scim.ag/4if1Mc5

Proud to share our group latest paper in Nature. "Spatial immune scoring system predicts hepatocellular carcinoma recurrence." A game-changer for early-stage HCC management - high risk patients benefited from Immunotherapy - Dawn of Spatial Medicine? nature.com/articles/s4158… Our

it’s a wrap for a side project of my postdoc stint, learning more about B cells plasticity

Adaptive NK Cells Exhibit Tumor-Specific Immune Memory and Cytotoxicity in Ovarian Cancer aacrjournals.org/cancerimmunolr…

NK cells are not T cells. How we target them in immunotherapy strategies must respect this. Some fresh thoughts on this from our team 👇

1/ Doing bioinformatics is not just crunching numbers. It’s running experiments—just like a wet lab scientist does. But with code.

NK2026 in Italy September