Incredible example of a TFE3-rearranged PEComa that presented as a colorectal polyp.

Monomorphic epitheliotropic intestinal T cell lymphoma (MEITL), formerly termed Type II enteropathy-associated T cell lymphoma is NOT associated with celiac disease. #UMiamiPath

This biphasic synovial sarcoma presented as a colon polyp. Dr. Domenika Ortiz Requena from our department has published the largest series of such cases. Ortiz Requena D, et al. Synovial Sarcoma of the Gastrointestinal Tract. Mod Pathol. 2024 Jan;37(1):100383. PMID: 37972927.

These small intestinal biopsies from a patient with markedly elevated serum IgM from a splenic plasmacytoid extranodal marginal zone (mucosa-associated lymphoid tissue) lymphoma show dramatic edema and IgM deposition that resulted in malabsorption. There is no lymphoma.

gastric biopsy from an old man what do you think is going on here? #GIpath #PathTwitter

Colonic involvement by chronic lymphocytic leukemia/small lymphocytic lymphoma. Note the aberrant co-expression of CD5 and CD20.

Seen on endoscopy in the duodenum. What’s going on here?

Thyroid: Classification of Follicular-Patterned Neoplasms Dr. Nishino – 2025 Diagnostic Pathology Update #USCAP #pathology #PathTwitter #PathX

Amyloid deposition is common in patients with carpal tunnel syndrome, surprisingly so in this recent series. These images are of a Congo red stain, one using polarized light and showing apple green birefringence. PMID: 41345990.

Breast, 60y #pathology #patologia #pathoutpic #breastpath #breastpathology

#breastpath Beautiful myxoid fibroadenoma #PathTwitter

This sessile serrated adenoma (polyp, lesion) has dysplasia with loss of MLH1 (the case about half the time) and an associated benign perineurial proliferation. What more can a gal ask?

Do we grade thyroid cancer? Yes. Per 2022 5th WHO: If you have a histologically differentiated tumor - Papillary carcinoma - Follicular carcinoma - Oncocytic carcinoma with tumor necrosis (punctate to extensive, excluding FNA changes) or ≥5 mitoses per 2 mm², then you can call

Adult male with epigastric pain. Olaleke Folaranmi Celina Stayerman MD Lorand Kis Ankur Sangoi Tim Bracey Kalyani Bambal Adam L. Booth, MD

Thyroid neoplasms - Helpful IHC table Dr. Nishino - 2025 Diagnostic Pathology Update #USCAP #pathology #PathX

📊 Staging Cancer in Colonic Polyps 🔬 1️⃣ Polyp type: Stalked vs Sessile 🧐 2️⃣ Classification: Haggitt 🏷️ | Kikuchi 📏 Master staging & predict invasion risk like a pro! 🩺✨ #ColorectalPathology #Histopathology #FRCPathPrep #PolypCancer #ExamPrep #PathologyMastery

Another spectacular EBV-associated gastric carcinoma (gastric carcinoma with lymphoid stroma). This example has overt gland formation and more sheet-like areas.

This is an ordinary mantle cell lymphoma of the colon - presenting as multiple nodular areas. However, more aggressive subtypes are in a spectrum with large B cell lymphomas. Li S, Tang G, Jain P, Lin P, Xu J, Miranda RN, Cheng J, Yin CC, You MJ, Wang ML, Medeiros LJ. SOX11+

Sinonasal papilloma classification - Inverted type - Oncocytic type - Exophytic type Dr. Nishino - 2025 Diagnostic Pathologic Update #USCAP #pathology #PathX

🔬 Nephrogenic metaplasia in bladder ☑️Nonneoplastic reactive metaplastic lesion with tubular, glandular or papillary architecture. ☑️Most cases confined to lamina propria. ☑️May mimic urothelial carcinoma, clear cell or prostatic adenocarcinoma. IHC : AE1/AE3 , PAX8 , 5S04 +