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Arousal state dependence of the cortical blood volume - pupil diameter relationship biorxiv.org/cgi/content/sh… #biorxiv_neursci

Quantitative relationship between cerebrovascular network and neuronal cell types in mice cell.com/cell-reports/f…

Our neurovascular mapping paper Cell Reports shows striking correlation between vascular network/pericyte and cortical neuronal cell types in mice. doi.org/10.1016/j.celr…. Congrats Yuan Ting Wu Hannah Bennett Qingguang Zhang drew_lab

Beyond its direct metabolic role, oxygen may function in a modulatory fashion in the brain. Check out our drew_lab review of this speculative hypothesis in Pflugers Archiv - European Journal of Physiology. doi.org/10.1007/s00424…

very interesting perspective by Patrick Drew - why does neurovascular coupling exist? It argues against the idea that it serves neuronal metabolic needs, and instead for alternative functions: sciencedirect.com/science/articl…

Neural activity can drive changes in local blood flow. This link is often described as being required to supply the metabolic needs of neurons. Patrick Drew drew_lab outlines evidence questioning this view, and discusses alternative explanations: cell.com/trends/neurosc…

Ready to meditate by controlling your breathing? By simultaneously recording rsMRI, electrophysiology and respirational signals, we discovered a respiration-associated brain network mediated by neural activity. The paper just came out in eLife. doi.org/10.7554/eLife.… eLife - the journal

Relating pupil diameter and blinking to cortical activity and hemodynamics across arousal states biorxiv.org/content/10.110…

Did you apply yet? Applications are due on Monday, December 5th. Apply today. #STEMScholarship millennium.psu.edu/how-to-apply/

#ThrowbackThursday - well not so far this time. Maybe you missed this paper about respiration-driven blood oxygen levels modulating neural activity Qingguang Zhang drew_lab #brain #lung rdcu.be/c1sc2

Happy to share my paper diving into rodent pupil dynamics is now out. Being able to accurately and non-invasively sleep score with a single camera was fun. Relating Pupil Diameter and Blinking to Cortical Activity and Hemodynamics across Arousal States jneurosci.org/content/43/6/9…

Parvalbumin (PV) interneuron activity induces hemodynamic responses differentially under anesthesia and wakefulness. Check out the source of biphasic #fMRI responses (pnas.org/doi/10.1073/pn…). Great collaboration with drew_lab CNIR-IBS.

Parvalbumin interneuron activity drives fast inhibition-induced vasoconstriction followed by slow substance P-mediated vasodilation | Proceedings of the National Academy of Sciences pnas.org/doi/10.1073/pn…

We team up with drew_lab to examine anatomical and functional changes in aged mouse brain. We found that aging induces selective regional vascular and pericyte degeneration, slowed NVC response, and lower oxygen carrying capacity. biorxiv.org/content/10.110…

drew_lab, Kevin Turner, Nanyin Zhang, Qingguang Zhang show that sleep-related vascular changes dominate over sensory-evoked changes with a combination of optical imaging, electrophysiology, and BOLD fMRI in unanesthetized neonatal mice. nature.com/articles/s4200…

Patrick Drew (drew_lab) of Penn State Engineering Science and Mechanics has been named Associate Director of the Huck Institutes: psu.edu/news/faculty-a…

We are hiring a research technologist: psu.wd1.myworkdayjobs.com/PSU_Academic/j…

Patrick Drew (drew_lab), professor of engineering sciences and mechanics, of neurosurgery, of biology and of biomedical engineering and associate director of the Huck Institutes of the Life Sciences, has been selected to serve as interim director. psu.edu/news/huck-inst…

Aging vessel mapping paper is officially out. nature.com/articles/s4146… We examined structural and functional changes of cerebrovasculature and found brain region specific changes in normally aging C57 mice compared to young mice.

Type-I nNOS neurons orchestrate cortical neural activity and vasomotion doi.org/10.7554/eLife.…