Busy day in Leeds! Our research group was involved in these two important meta-analyses examining the risks associated with receiving placebo in induction and maintenance trials of biologics and small molecules in #IBD, which have just been published in The Lancet Gastroenterology & Hepatology

Really important research here - should we really be accepting placebo as the main comparator in IBD trials given the associated harm to our patients? DrShahidaDin Seb 𝗗𝗿 𝗔𝗷𝗮𝘆 𝗠 𝗩𝗲𝗿𝗺𝗮 Peter Higgins IBD Women Chris Lamb Christian Selinger BSG BSG Trainees

New study in ⁦⁦JAMA⁩: UC patients with HLA-DRB1*01:03 face higher risk of severe Disease. 42% of carriers require major IBD surgery within 3 years vs 9% of non-carriers ⁦@marie_vibeke⁩ ⁦Aleksejs Sazonovs⁩ ⁦⁩ Tine Jess⁩ linkedin.com/posts/center-f…

Frailty rather than age matters when making decisions for older patients with IBD. Read our newest review in JCC. academic.oup.com/ecco-jcc/artic…

Excellent letter in Telegraph today. We are in the NHS family and don’t have customers we can charge more to offset this cost. This will lead to less doctor, receptionist and nurse time. #GPNIBombshell

Thanks to Millie Long and Joana Torres for a fabulous meeting learning from some great Women in IBD. Great talks, discussions and networking. Particularly inspiring talks from Maria T. Abreu Tine Jess iris dotan and many more!

Efficacy and safety of mirikizumab in patients with moderately-to-severely active Crohn's disease: a phase 3, multicentre, randomised, double-blind, placebo-controlled and active-controlled, treat-through study thelancet.com/journals/lance…

#SundayRead☕️ #IBD therapies & serious AE at 3yrs 🔺Biologics: ⬇️risk CV (MI, stroke), VTE, mortality vs non users 🔺Small molecules: No differce in AE vs nonusers, but ⬇️overall mortality, incl. in🔺Pt> age50 +CV risk factor IBDJournal & CC360 Dina Alayan doi.org/10.1093/ibd/iz…

New guidance highlights the risks of Tofacitinib, Filgotinib, Upadacitinib, and Ozanimod for #IBD in women of childbearing age. These therapies should be avoided during pregnancy/breastfeeding, with alternatives recommended pre-conception 🔗 journals.sagepub.com/doi/epdf/10.11…

Very excited to share our IBD multi-biome analysis evaluating bacteriome, phageome, mycobiome, and their interactions. We found the distinct multi-kingdom interactions of the gut microbiome in UC and CD. Suguru Nishijima, #NaoyoshiNagata, Nature Communications nature.com/articles/s4146…

Post hoc analysis of the OASIS and ELEVATE UC trials shows non-serious adverse events (eg. headache, dizziness) were slightly more frequent with etrasimod vs placebo in UC patients, but all events were short-lived, reaffirming etrasimod's safety profile 🔗journals.sagepub.com/doi/epdf/10.11…

👏🏽Beatriz Gros Jellyana Peraza MD Lauren Tal Grinspan Aline Charabaty, MD, FACG, AGAF systematic assessment of gender & race representation in IBD clinical trial authorship. Acknowledgement=understanding the leadership journey& building inclusive solutions👌🏽Journal of Crohn's and Colitis BSG BSGSWiG SSG

More systemic adverse events & infections in placebo-controlled trials in #IBD. Something many of us patients & physicians have been advocating against. We need the U.S. FDA to help us & seriously consider comparator agent trials now that we have more therapies 🙏🏽 #AIBD2024

Open-access nature paper from the GIVES-21 consortium, co-led by Siew Ng and I, funded by Helmsley Charitable Trust, and supported by IOIBD, reveals the global evolution of IBD across epidemiologic stages. Co–first authors: Dr. LD & @LingWWindsor nature.com/articles/s4158…

Over a decade since I collaborated with world-class epidemiologist Gil Kaplan MD MPH and his team, here is our long awaited paper out in nature reporting for the first time evolution of #ibd across 4 stages Helmsley Charitable Trust IOIBD CUHK Medicine GIVES-21 nature.com/articles/s4158…

Could not be more pleased that 2⃣ colleagues King's College London awarded prizes at #BSGLIVE25 BSG RCTs of Diet in GI getting attention they deserve! Aaron Bancil won Gut Journal Best Laboratory Science Prize Dr Simon Steenson won BMJ Open Gastro Best Clinical Science Prize

The Online Small Bowel Reading Course is designed to train aspiring practitioners to perform & read full capsule studies reliably. Training is most suited for experienced GI consultants, colorectal surgeons, specialist trainees & nurses. More at shorturl.at/KtBEB

BSG IBD July 2025 newsletter available: huge🙏🏽 for supporting our work streams. Several ways to influence IBD care universally 🗺️ details on current projects, meetings, opportunities. #DrGarethParkes bsg.org.uk/ibd-newsletter Y-ECCO UEG Week