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🧩Neurohormonal blockade in transthyretin amyloidosis, perhaps one size does not fit all? European Society of Cardiology Journals #Cardiology #CardioEd #Amyloidosis

Another great report from Marianna Fontana et al at the NAC 3 patients, 2 w/ V122i and 1 wild type, all with significant ATTR-CM burden clinically, spontaneously developed IgG antibodies against non native ATTR with impressive regression #CardioTwitter nejm.org/doi/full/10.10…

Very excited to see our QIP written up 🤩 Huge thanks to all involved and to all teams that made this the success it was!

Appreciation of the unique features of Apolipoprotein AI, and ability of AApoAIV to mimic common forms of cardiac amyloidosis is urgently needed to reduce risk of misdiagnosis Adam Ioannou marianna fontana #AHAJournals Allison G. Hays, MD ahajournals.org/doi/abs/10.116…

Congratulations George Joy

🔵 Rare Forms of Cardiac Amyloidosis: Apo AI & AIV Amyloidosis Circulation #Cardioed #Cardiology #Amyloidosis #CardioTwitter

Rare Forms of Cardiac Amyloidosis: Diagnostic Clues and Phenotype in Apo AI and AIV Amyloidosis CircImaging ahajournals.org/doi/10.1161/CI…

Don’t forget the rare forms of cardiac amyloidosis! ahajournals.org/doi/epub/10.11…

⚠️ Conventional heart failure therapy in cardiac ATTR amyloidosis‼️ 📍 Beta-blockers and ACEi/ARBs were often discontinued, but low-dose BB were associated with ⬇️ risk of mortality in LVEF ≤40% 📍 MRAs were rarely discontinued and were associated with ⬇️ risk of mortality

New "Focus Issue" on heart failure (HF) and cardiomyopathies is out! don't miss the late breaking trials in heart failure. doi.org/10.1093/eurhea… #HF #cardiomyopathy #cardiotwitter European Society of Cardiology Journals European Society of Cardiology

From current issue: new study assessing prescription patterns, discontinuation rates, and prognosis of conventional heart failure medications in patients with transthyretin cardiac amyloidosis doi.org/10.1093/eurhea… #HF #amyloidosis #cardiotwitter European Society of Cardiology Journals European Society of Cardiology

Predicting #amyloidosis treatment response via #WhyCMR #ECV? In this study of n=351 + n=171 w/ follow-up imaging, baseline myocardial & liver ECV + CV changes at 6 months predicted mortality. bit.ly/45fYRcY #JACCIMG #CardioOnc #CardioTwitter Adam Ioannou marianna fontana

Albuminuria in cardiac ATTR amyloidosis 1. Present in nearly half of patients 2. Patients had a more severe cardiac phenotype 3. At diagnosis albuminuria is associated with mortality 4. Significant increase during follow up is associated with mortality onlinelibrary.wiley.com/doi/10.1002/ej…

Multiorgan blood biomarker abnormalities are common and associated with mortality in ATTR-CA. #AHAJournals Adam Ioannou ahajrnls.org/3wrNr9A

Presented at #ACC2024 and #SimPub in JACC Journals NT-proBNP progression and ODI detect disease progression and are associated with an increased risk of mortality in cardiac ATTR amyloidosis jacc.org/doi/10.1016/j.…

An excellent investigation into 6MWT prognostic value in #ATTR #CM by the NAC (Adam Ioannue, Marianna Fontana et al.) in JACC Journals I wrote an editorial putting the study into context based on what we have learned recently Turning Meters into Years: Walking to Survive

Presented at ESC heart failure 2024 with a simultaneous publication in JACC Journals #HeartFailure2024

Expansion of the NAC staging system to detect early mortality in ATTR-CM🫀 Important for: 🔬clinical trial inclusion criteria 💊potential intensified treatment Adam Ioannou marianna fontana onlinelibrary.wiley.com/doi/10.1002/ej…

🔴 The Last Decade in Cardiac Amyloidosis: Advances in Understanding Pathophysiology, Diagnosis & Quantification, Prognosis, Treatment Strategies & Monitoring Response JACC Journals #Cardiology #cardioEd #cardiotwitter #Amyloidosis

The Last Decade in Cardiac Amyloidosis: Advances in imaging 🧲have transformed diagnosis & treatment. Read more: tinyurl.com/Amyloidai Marianna Fontana James moon Sharmila Dorbala Adam Ioannou BSCMR President SaulMyerson