Stability Bias: matthewrocklin.com/engineering/st… New Post Folks often avoid committing to changes that have negative consequences, even if they also have positive consequences, especially for new or future users.

Lots of exciting force field science coming soon!

Arizona is divided. But the path forward is clear — we need to work together, across parties, to mend fences and heal our divisions. It’s time to leave the past behind and look forward into the future. As your governor, I’m going to do just that.

Creative work is an emotional rollercoaster. One minute you can feel inadequate and out of your depth, and the next like a damn savant.

Open Force Field BespokeFit: Automating Bespoke Torsion Parametrization at Scale #cheminformatics pubs.acs.org/doi/10.1021/ac… Joshua Horton @Yoshanuikabundi David Dotson Venkata Krishnan David Mobley John Chodera (he/him) Cresset Cole Group #vol62 #issue22 #JCIM #compchem

A desert gives the gift of clarity, vision.

We are proud to be a part of the ASAP <asapdiscovery.org> Discovery team and do our best to pursue the development of new antivirals for future pandemics, (ASAP Discovery). Many thanks to John John Chodera (he/him) and the team for organizing this important meeting!

And David Dotson is wrapping up the morning session with discussing #alchemiscale as shared infrastructure created from a shared need between multiple projects.

I am my happiest when I am building something with clarity of purpose, aligned with my values.

🚨ANNOUNCEMENT🚨 The COVID Moonshot is now published in Science Magazine! The paper reflects the major contributions of the FAH community and a global network of scientists collaborating to make drug discovery open, globally accessible, and affordable scim.ag/4LB

Delighted for Folding@home to have helped with this exciting drug discovery achievement!

Probably the most important/impactful scientific paper Ive been part of. Very excited to continue this work with ASAP Discovery as a member of the John Chodera (he/him) lab. Also excited to work on Open Free Energy to build a fully open source pipeline for binding free energy calculations

I am so happy to see this. A big round of applause to the team for this heroic effort!!!

Gave an invited talk a few weeks back at Memorial Sloan Kettering Cancer Center on alchemiscale (github.com/openforcefield…), and how we're working to scale out alchemical free energy calculations to support open data antiviral discovery for ASAP Discovery via Folding@home.

Save the Date: bit.ly/FEWorkshop25 We are happy to announce the dates for the Free Energy Workshop 2025! Please fill out the above form to register your interest and you will receive all updates concerning registration and abstract submission! #Alchemistry2025

I'm very pleased to announce the launch of #OpenADMET -- a new Open Molecular Software Foundation project and part of a much larger #Avoidome initiative led by James Fraser (A$AP J) John Chodera (he/him) and Sri Kosuri , and funded by ARPA-H.

Do you use alchemiscale in production? Or would you like to? We recently shared a perspective on the progress of the project, where we're currently focused, and the opportunities we see for advancement in 2025: alchemiscale.org/opportunities/… Let us know what you think! #drugdiscovery

🦠 We’re excited to announce our first competition in partnership with ASAP Discovery and Open Molecular Software Foundation! Test your skills across three sub-challenges revolving around SARS-CoV-2 and MERS-CoV Mpro: 🧩 Ligand Poses: Given a training set of SARS-CoV-2 Mpro X-ray structures, predict

Just found out that Dignity Health in Arizona no longer takes *any* Marketplace insurance plans. So if you're self-employed, pay for your own insurance, and need to see a specialist who happens to be in their sprawling network, sucks to be you. "Hello Humankindness" indeed. 🫠