Epigenetic regulatory layers in the 3D nucleus dlvr.it/T2GFdb

DNA-PAINT imaging inside the nucleus at single antibody resolution using TIRF? Ultrathin cryosectioning makes it possible! Excited to share our preprint introducing “tomographic & kinetically-enhanced DNA-PAINT”/ tokPAINT! biorxiv.org/content/10.110… Our findings…: [1/11]

📚 Learning and Memory Problems in Down syndrome Linked to Alterations in Genome's ‘Dark Matter’ Researchers at #CRG led by Mara Dierssen and Cesar Sierra as first author, reveal that the Snhg11 gene is critical for the function and formation of neurons in the hippocampus.

Our paper uncovering the role of SRRM2 splicing factor in stem cell pluripotency is published Biology Open! 🚀 Huge joint effort coming from PomboLab @BioComicsLab Sílvia Carvalho Prof Ana Pombo MDC-BIMSB UCIBIO Faculdade de Ciências e Tecnologia | NOVA FCT doi.org/10.1242/bio.06… ↓ Short thread below ↓

I am very pleased to share that our latest research🧑‍🔬 from PomboLab, about allele-specific chromatin structure 🧬, now live on bioRxiv. Shout out to Prof Ana Pombo, Alexander Kukalev, Rieke Kempfer and the rest of the team for this remarkable work of science. ↓ Short thread below ↓

Given the post-pandemic surge in global cocaine and poly-drug use, as well as the ongoing opioid crisis in North America, there is an urgent need to understand the effects of initial exposures to drugs of abuse and the inception of addiction. 2/6

Two latest cool 3D genome structure preprints bioRxiv from Prof. Ana Pombo's lab PomboLab: 1. A single dose of cocaine rewires the 3D genome structure of midbrain dopamine neurons biorxiv.org/content/10.110… 1/2

Happy to share the final version of our #GAGEseq published today Nature Genetics! The single-cell co-assay for #scHiC and #scRNA reveals 3D genome & gene expression interplay in mouse cortex (also integration w/ #MERFISH) and during human hematopoiesis. 1/3 nature.com/articles/s4158…

Do you know that almost one in every two Europeans will suffer from a brain disorder? Do you know that brain research in Europe is underfunded compared to other areas? In the European Elections Vote for the candidates that support #BrainHealth & research!

Join our lab Karolinska Institutet in Stockholm!! We have PhD positions open in single-cell and spatial omics, check it out at: kidoktorand.varbi.com/en/what:job/jo…

Incredible how this field has evolved over the last 50 years 🤯 Both from a methodological 🧬 and from a computational 🖥️ perspective. Such a challenging problem that seems to be solved now..

🚨 Job alert Hiring a postdoc (comp or wet lab) to work on chromatin & genetics 🧬 Come work with us Centre for Human Genetics in the beautiful University of Oxford 🗓️ Closing September 13th Details at beagrielab.com/join Pls share and RT! #PostdocJobs #GeneticsJobs #genomics #cohesin

The call is out for the new #DFG #PriorityProgramme on the epigenetic regulation of neurodevelopment. Initiated by Tanja Vogel with support from Geraldine Zimmer-Bensch, André Fischer, Prof Ana Pombo and myself. Looking forward to exciting insights from #EPIADAPT! More details 👇👇👇

📣WE ARE HIRING📣 We are looking for a laboratory technician to work with us in the Laboratory of Transcriptional and epigenetic mechanisms of neuronal plasticity based at the Instituto de Neurociencias UMH-CSIC. 🔽Check it out! 🔽

🚨Inter-chromosomal contacts (‘kissing chromosomes’) organize human genome topology along a spatial gradient of genome activity (62 Hi-C datasets). Check rdcu.be/dZYQw, Nature Communications, 4DNucleome, The 3D Genome, Human Genome Org, Network Science Society, @Emblebi, @MoGen_Grads

#JNeurosci | Federico Miozzo 🇪🇺🇺🇦 et al. used mice to investigate how a gene associated with autism spectrum disorder and depression, Protocadherin 9, plays a role synaptic dysfunction and brain pathology. This study provides important molecular and synaptic insight. Instituto de Neurociencias UMH-CSIC

Two weeks left for application. Projects for neurogenomics in Denmark!

Congratulations, Ana Pombo! The #mdcBerlin scientist is awarded Germany's most important science prize: the Gottfried Wilhelm Leibniz Prize by the German Research Foundation (DFG public | @[email protected]). More about Prof Ana Pombo and her work: mdc-berlin.de/news/news/ana-… MDC-BIMSB Helmholtz

🏆 Huge congratulations to Ana Pombo for receiving Germany's most prestigious scientific award, the Gottfried Wilhelm Leibniz Prize, for her groundbreaking research on 3D genome architecture & gene regulation! #mdcBerlin