How to write a grant? 1. Write it for the reviewer, not you, the applicant. 2. Communicate in stories. 3. Make your story cohesive—leave no puzzling gaps. 4. Make your story resonate to keep the reviewer reading. 5. Accept chance and noise in peer-review. pnas.org/doi/epub/10.10…

The maternal-to-zygotic transition: reprogramming of the cytoplasm and nucleus go.nature.com/3On9T9s #Review by Mina Kojima, Caroline Hoppe & Antonio J. Giraldez Giraldez Lab Yale University

A very timely update on MZT!

À la recherche d'un stage d'été? Envie de poursuivre tes études aux cycles supérieurs? Viens nous rencontrer, nous recrutons! ✏️Pour t’inscrire, date limite 9 janvier : forms.gle/62SHuiSsmCjSVG…

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from transgene expression and real-time

Lessenger, Skotheim, Swaffer, and Feldman Stanford University show that developmentally regulated #polyploidy in the #Celegans intestine is essential for cell size, production of highly expressed transcripts, tissue function, and organismal fitness. hubs.la/Q02-Y8FS0 #Development

We are excited to introduce first-of-a-kind immunofluorescent probes to visualize RNA in cells! Nucleic Acids Res Synthetic anti-RNA antibody derivatives for RNA visualization in mammalian cells academic.oup.com/nar/article/do…

The geometric basis of epithelial convergent extension. elifesciences.org/articles/95521…

Thrilled to share our first independent manuscript! We reveal that recurrent mutations in ZC3H18 stabilize endogenous retroviral RNA, which contributes directly to oncogenesis. Thanks to The Spliceosome Zone, Burns Lab, @NCIChanock, @kbrowngenetics and the rest of our co-authors!

Okay, another VERY exciting paper drop! 🎉📜 So you guys may know the story of how Gameto was started? 🐣 My part of the story begins with a visit to george church at Harvard Medical School, with a (perhaps naive) goal: to make an oocyte from a stem cell. 🧫 With Gameto's support, I

Nature research paper: Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy go.nature.com/3CW8nZS

What happens when a modern human-specific amino acid in a neuronal RBP is introduced in a mouse? Please check if this question sounds interesting to you! Happy to see this published. Congrats to the whole team! nature.com/articles/s4146…

A surprising discovery by Bojan Bujisic et al: The RNA component (7SL) of SRP regulates a global response to stress — controlling both transcription and translation. 7SL RNA is not just for ER translocation! Read about the findings here: rdcu.be/d9S1q

Cellular responses to RNA damage: Cell cell.com/cell/fulltext/…

Quite an essay on the basis of cancer entitled "The End of the Genetic Paradigm of Cancer" PLOS Biology arguing against the primacy of somatic mutations and cells (traditional model), invoking gene regulatory networks and tissue journals.plos.org/plosbiology/ar…

Our new story is out Nature Communications thanks to Grosshans Lab and Antoine Dufour labs for their contribution and for the financial support of CIHR, FRQ - secteur Santé and NSERC / CRSNG nature.com/articles/s4146…

New paper out in Biochemistry! We lay out a roadmap for targeting human RNAs with small molecules—focusing on genetically validated targets, functional binding sites, and cellular activity. A step toward unlocking RNA’s drug potential. pubs.acs.org/doi/10.1021/ac… #RNA #DrugDiscovery

What protects individuals from developing blood cancers? Thrilled to share my work in Vijay Sankaran lab, describing inherited resilience protecting blood stem cells from clonal hematopoiesis by modifying RNA regulation. 🧵👇(1/n) biorxiv.org/content/10.110…

🚀Prêt·e à lancer ta carrière de chercheur·e ou à changer de décor? Ready to launch your research career or change the scenery? Oncologie | Oncology Le Centre de recherche du CHU de Qc-Université Laval t’attend dans la magnifique ville de Québec! 👉bit.ly/44vht9X #ScienceJobs #postdoc #facultyjobs #AcademicJobs

How embryos stay “on time” as they grow? Happy to share our recent publication: Quantitative modeling of mRNA degradation reveals tempo-dependent mRNA clearance in early embryos (1/7) academic.oup.com/nar/article/53…