1 Excited to share my Ph.D. work Crane Lab on circadian rhythm research, now published in Nature (rdcu.be/daNXa)! We've unveiled the structure to better understand the complex dance between the clock timing proteins Cry and Tim in fruit flies #circadianrhythm

Super excited that this paper is now out at Nature Communications nature.com/articles/s4146…. If you want to use X1.1 AAV for specific targeting of brain vasculature, check out addgene.org/196836/

How do the ovary and the brain interact with each other? Eager to explore? Wish to find solutions for neuronal-related infertility? The Kahan lab is coming soon! PhD and MSc positions are open! anatkahan.wixsite.com/kahan-lab

Our lab (Viviana Gradinaru Lab) at Caltech (glab.caltech.edu and clover.caltech.edu) has multiple open positions, join us at the sunny south California! #apply through the 2 postings below: lnkd.in/g7QrKU3r lnkd.in/gShEdPsP (updated from prior posting)

A new case for AI-Driven Drug Design: Machine learning for potion development at Hogwarts. arxiv.org/abs/2307.00036 The ethical worries about these methods being exploited for The Dark Arts should not be taken lightly.

GPT-4 is getting worse over time, not better. Many people have reported noticing a significant degradation in the quality of the model responses, but so far, it was all anecdotal. But now we know. At least one study shows how the June version of GPT-4 is objectively worse than

The PDB50 board game explores the process of structure discovery. Available for download or Tabletopia Board Games 🎲 #gencon pdb101.rcsb.org/learn/other-re…

Honored to be selected as a Damon Runyon Fellow! Thank you Damon Runyon Cancer Research Foundation, Connie and Bob Lurie for your strong support. Also grateful for the backing from my current labs @MarsonLab Jonathan Pritchard and former colleges ElowitzLab, Jordi Garcia Ojalvo, Justin Bois, Matt Thomson & others.

Very excited to share our work at Google DeepMind on missense variant pathogenicity prediction using AlphaMissense, new in @sciencemagazine doi.org/10.1126/scienc…. Long 🧵focused on more technical details. 1/

Can we image intracellular calcium with ultrasound? Yes, w/ultrasonic reporters of calcium - URoCs! Congrats to Zhiyang Jin and co-authors on creating the first genetically encoded acoustic biosensors of this universal cell signal based on #gasvesicles. biorxiv.org/content/10.110…

Today I want to share two stories of my postdoc research Doudna Lab. The first project in collaboration with the Murthy lab at Berkeley describes our work on “lung and liver editing using lipid nanoparticle delivery of a stable CRISPR-Cas9 RNP”. biorxiv.org/content/10.110…

Professionalism

I am beyond excited to share a new paper “Rapid, concerted switching of the neural code in inferotemporal cortex,” led by Yuelin Shi and Dasheng Bi. We describe a new form of neural computation in which single neurons rapidly change their tuning to temporally multiplex different

A PhD of tubes 😅

Thrilled to share our latest publication in ACS Central Science! We developed an enzymatic platform enabling alkyl/aryl nitrene transfer for intramolecular C-H amination, which provides a novel approach to synthesizing N-heterocycles in biological world! See here: pubs.acs.org/doi/10.1021/ac…

Our work on studying chromatin context-dependent regulation of prime editing is officially out on @Cell. cell.com/cell/fulltext/…

Thanks for creating this excellent summary, it’s the best I’ve found. Uri’s piece helped me when I started grad school and again when starting a company. The lessons here also apply to startups, perhaps even more as the timescale can be longer

⭐️ Big news! HHMI is investing $300+ million in 26 new #HHMIInvestigators from 19 US institutions. These top scientists will drive groundbreaking research in diverse fields, from neuroscience to immunology to structural biology & beyond. Welcome to HHMI! hhmi.news/4df2eVs