Archiv der Pharmazie

Glad to have latest publication @Wiley Archiv der Pharmazie. lnkd.in/dG3gNmqA

The Stimulator of interferon genes (STING) is key to the innate immune system's response to pathogenic DNA. STING dimers in the ER change shape upon binding the secondary messanger cGAMP (green), and this allows them to oligomerize and move to the Golgi. #blender #b3d #sciart

Latest article: Chitosan with pendant (E)-5-((4-acetylphenyl) diazenyl)-6-aminouracil groups as synergetic antimicrobial agents doi.org/10.1039/D2TB00… J. Mater. Chem. family Royal Society of Chemistry DEEPTHI RAMESH

🔥 New advance article for RSC Chemical Biology! 🔥 Nathan W. Luedtke et al McGill University exploring [4 + 2] and [2 + 4] #cycloaddition reactions on single- and double-stranded DNA! #chembio #bioorthogonal 🧐Read the #OpenAccess article 👉ow.ly/gpAq50J8LaQ

PERSPECTIVE in Journal of Medicinal Chemistry- Mechanistic Insights for Drug Repurposing and the Design of Hybrid Drugs for Alzheimer’s Disease pubs.acs.org/doi/10.1021/ac… m Repurposing repurposing m development ATTAPONG's disease Demnetia ACS Publications

This is in my eyes the most important annual paper for students preparing for a job interview in medicinal chemistry (or process chemistry): provides a great overview about representative drug structures, their targets & synthetic routes used. ACS Publications Bio & Med Chem Content pubs.acs.org/doi/10.1021/ac…

Here's the slide that took me 6 months to make. The six classes of molecular interactions for drug design. Clearly H-bonds are the first thing to master as a drug designer followed by pi-pi and sigma-sigma interactions.

Researchers have discovered the first known "virovore," an organism that feeds on viruses. Probably there are many others like it -- an entire, previously unknown food chain. One day into 2023, and already things are going topsy turvy. eurekalert.org/news-releases/… #ecology #life

Lipinski’s Rule of 5 has been highly influential in guiding Med Chem in the past 25 years. What does it offer for the next 25 years of drug discovery? Ingo Hartung and colleagues provide answers here: nature.com/articles/s4157…

Over the last 10 years, the #CRISPR toolbox and its applications have profoundly changed biological research, enabling advances through applications in plants, animals, and humans. A recent #ScienceReview highlights a decade of the technology: scim.ag/1py

First woman possibly cured of HIV by transplanting HIV-resistant stem cells from umbilical cord blood. Deborah Persaud, M.D. UCLA Read more in Cell

Incredibly useful "cheatsheet" on cancer chemotherapy classes. From Cell Press sciencedirect.com/science/articl…

Discovery of an Oral, Beyond-Rule-of-Five #Mcl-1 Protein–Protein Interaction Modulator with the Potential of Treating Hematological Malignancies pubs.acs.org/doi/10.1021/ac…

Seeking postdoc position #polymer #medicinal #biomaterial #postdoc Please feel free to reach out if you have any inquiries or potential opportunities to discuss. vgbalaji.com scholar.google.com/citations?user… linkedin.com/in/dr-balaji-g… orcid.org/0000-0003-0126…

DEL-Dock: Molecular Docking-Enabled Modeling of DNA-Encoded Libraries #MolecularDynamics pubs.acs.org/doi/10.1021/ac… Kirill Shmilovich Theofanis Karaletsos Vol63 Issue9 #JCIM #compchem

Celebrating new publication. We demonstrate novel #imidamide based linkage for attaching #smallmolecules based on #drugdesign principles to #chitosan. lnkd.in/gZhEq9b6 #polymer #biomaterial #Researchpaper #postdoc #Chemistry #biopolymer

Here are the ten approved HIV protease medicines. The first nine all used the same design strategy to address the flap water. The last took the alternate approach and replaced it. mcconnellsmedchem.com/2023/06/17/wha…

Workflow for E3 Ligase Ligand Validation for PROTAC Development | ACS Chemical Biology pubs.acs.org/doi/full/10.10…