Doudna Lab @igisci @enrique_lins We also create a new fusion protein of Cas9 to PRDM9, a methyltransferase involved in meiotic recombination. The fusion protein decorates chromatin at target sites with H3K4me3 and H3K36me3 and improves HDR efficiency and HDR:indel ratio at multiple genomic loci.

This is an excellent commentary from Melinda Mills & Iain Mathieson on our recent IMR GWAS paper with Yuchang Wu Jason Fletcher. The comment on population stratification is great summary of the challenges we faced in the study and shed light on some general problems with GWAS too

here is the clip - first it's cos girls don't like the maths, which is then "a natural thing" and then she's totally fine with physics a-level only being 16% girls.

in which many eminent female scientists get to respond and express their own outrage and disappointment theguardian.com/education/2022…

Really extraordinary data visualization here. Outstanding work nytimes.com/interactive/20…

watching the amazing Prof. Simon Myers Weldon Memorial Prize Lecture - 'Cracking the code of sexual reproduction and speciation' 🧬✨ Centre for Human Genetics Oxford Statistics youtube.com/watch?v=_K-_Rq…

Release of pre-computed polygenic scores for UK biobank participants. Scores for 36 diseases/traits are available for everyone. Scores for additional 17 traits are available for ~100k individuals. More details -> medrxiv.org/content/10.110…

1/11 #medRxiv paper alert: “UK Biobank release and systematic evaluation of optimised polygenic risk scores for 53 diseases and quantitative traits” with UK Biobank and Genomics England medrxiv.org/content/10.110…. The traditional tweetorial follows...

The right to exit is the most important right. Times are volatile. Laws can change overnight. You might one day find yourself outnumbered by a suddenly hostile population. Exit is the right to travel, to leave, to opt-out. It’s what you need when the system fails.

Here's a brief glimpse of our INCREDIBLE near future. GPT-3 armed with a Python interpreter can · do exact math · make API requests · answer in unprecedented ways Thanks to Riley Goodside and Amjad Masad for the idea and repl! Play with it: replit.com/@SergeyKarayev…

Publicly Available Privacy-preserving Benchmarks for Polygenic Prediction biorxiv.org/content/10.110…

History is largely told as a series of political revolutions and wars. But what shape people's lives most are new inventions like the contraceptive pill or ideas like those in Newton's Principia Mathematica. That's what history should be about. worksinprogress.co/issue/history-…

Science ran a big experiment on itself for the last ~60 years. It didn't work out. experimentalhistory.substack.com/p/the-rise-and…

“We are aiming for personalised prevention to become routine in the health service in five or 10 years’ time" - Peter Donnelly 📰 UK to embark on groundbreaking new #genomics projects ✏️ Clive Cookson Financial Times ft.com/content/f4a68a…

A guide to air purifier metrics: - What is CADR? - How is it measured? - What is a typical CADR value? - How does it relate to pollution levels a) over time and b) at steady state? danielwells.me/posts/air-puri…

1/13 Our evaluation of the UK Biobank Polygenic Risk Score (PRS) Release (Version 2, May 2024) is now out in @plosone (doi.org/10.1371/journa…), with @Genomicsplc UK Biobank @genomicsEngland. The traditional tweetorial/Xorial follows…

Backups with Restic: understanding repository structure and a comparison with Git danielwells.me/posts/restic-d…

1/10 We’re excited to announce the publication of our work with Stanford Medicine, examining the premature deaths that would be saved if PRS-guided screening was introduced across seven common disease screening programs nature.com/articles/s4146…

Logistic regression with JAX (and Flax) danielwells.me/posts/jax-logi…

Breaking multilayer perceptrons danielwells.me/posts/breaking…