News: NIH clinical trial of universal flu vaccine candidate begins dlvr.it/Sw8vSD

Great work by Matt Matt Vukovic investigating what the monoclonal antibody response looks like when you optimize an HIV vaccine for strain breadth, bnAb sensitivity, and minimizing shared glycan holes

A collaborative effort led by PhD candidate Steven Wall shows that #antibodies from children exhibit broad #SARSCoV2 neutralization, including against highly resistant #virus variants, but have similar sequence features compared to adults: Cell Reports Medicine cell.com/cell-reports-m…

This paper, led by Ph.D. candidate Matt Vukovich, is now published in ASM Journal of Virology: journals.asm.org/doi/10.1128/jv…

A protective pan-betacoronavirus #antibody that also recognizes zoonotic alpha- and delta- #coronaviruses. Multi-year effort led by Nicole Johnson, Steven Wall, Kevin Kramer, vaccine_clint, in collab with Jason McLellan, Giuseppe Sautto, and many others. biorxiv.org/content/10.110…

I'm excited my friend Alex's work has been published and that I was able to take part! Another example of LIBRA-seq identifying ultra-potent antibodies while only requiring a handful to be tested in the lab.

Watching this closely: Transmission of Highly Pathogenic Avian Influenza between mammals is concerning. "...the virus may be transmitted from cow-to-cow, in addition to previous reports indicating cattle were acquiring the virus from infected birds." tinyurl.com/4dz2zvbm

Not sure it is a good time for this....H5N1

Our group has multiple #postdoc openings in the area of #antibody discovery and #vaccine design, both for experimental and computational scientists. Please reach out if interested.

Online now! Discovery and characterization of a pan-betacoronavirus S2-binding antibody dlvr.it/TDgKMN

Happy to be part of a disruptive project out of my lab. Essentially #ChatGPTForAntibodies — feed in an antigen sequence and it returns an antibody sequence that has a high probability of binding.

Using #antibody sequence alone, can we predict whether two antibodies target overlapping epitopes? A new suite of algorithms developed by vaccine_clint: Contrastive Learning Enables Epitope Overlap Predictions for Targeted Antibody Discovery biorxiv.org/content/10.110…

An ambitious project led by Vanderbilt Health investigators aims to use #AI technologies to generate antibody therapies against any antigen target of interest. Ivelin Georgiev, Ph.D. will serve as the project principal investigator. news.vumc.org/2025/03/10/vum…