Now Online C-degron mimicry confers E3 ligase selectivity dlvr.it/SkqCmx

📣 Amazing News! We're happy to announce, that Brenda Schulman receives an ERC Advanced Grant for her project UPSmeetMet! Congratulations to all ERC-Awardees! 🎉 ➡️ more: biochem.mpg.de/brenda-schulma… European Research Council (ERC) #ERCAdG #Ubiquitin

Systemwide multiprotein complex formation visualized! CAND1 recycles Cullin-RING complexes to produce E3 #ubiquitin ligases. Averts cellular supply chain problems, prevents buildup of unneeded molecular machines & rapidly establishes degradation pathways ➡️tinyurl.com/bdnz25d6

In preparation for the Louis-Jeantet Prize ceremony, we accompanied the Louis-Jeantet Foundation / Fondation Louis-Jeantet video team to shoot parts of the video about our director Brenda Schulman, Ivan Đikić and their amazing research in the #ubiquitin field. Watch the full video here: ➡️ youtube.com/watch?v=UDBQOR…

Which cullin-RING E3 #ubiquitin ligase directs your favorite pathway or your #DegraderDrug? Our conformation specific antibody and probing of active #CRL E3 complexes is in Nature Chemical Biology! ❕mpg.pulse.ly/3m3asipuew ❕nature.pulse.ly/l6c644umev Matthias Mann Lab Peter J Murray Lukas Teoman Henneberg

How does multisite #phosphorylation of an #E2 enzyme dictate its pairing with a multisubunit #E3 #ubiquitin ligase to regulate metabolism? Check out our story available now in Molecular Cell! ➡️ cell.com/molecular-cell… D.Sherpa Schulman lab Max Planck Institute of Biochemistry (MPIB)

How does multisite #phosphorylation configure the catalytic E2-E3 assembly for metabolic enzyme targeting? Check out our story available now in its final version in Molecular Cell! ❕cell.com/molecular-cell… Jakub Chrustowicz D.Sherpa #ubiquitin

Now out in Molecular Cell! High-resolution structure showing direct ubiquitylation of a #TPD substrate! And much more, check out 👉shorturl.at/jrsBG #cryoEM Max Planck Institute of Biochemistry (MPIB) UNLV College of Sciences St. Jude Research @DanielS20127197 rajan prabu (1/2)

Back after an Easter X-break with a new paper from PhD student Annette Gross, Arno Alpi and the Schulman team explaining how the huge spectrum of WDR26 mutations is involved in #Skraban-Deardorff intellectual disability syndrome

Here is the link to our SKDEAS paper: 10.1002/1873-3468.14866. And I love this figure. Maybe useful for the @Skdeas.org effort.

🚨Excited to share that our manuscript is now published in NatureStructMolBiol. Using #cryoEM 🔬we obtained multiple snapshots 📷 of the #chaperone-mediated multistep assembly pathway of the human 20S #proteasome. Max Planck Institute of Biochemistry (MPIB) @HarvardCellBio Aligning Science Across Parkinson’s nature.com/articles/s4159…

Wow! CUL9 is a GIANT E3 ubiquitin ligase!  See unique cullin-RING-RBR all-in-one. +/- NEDD8. Now online in Nature Structural & Molecular Biology by Schulman Department ❕nature.com/articles/s4159… #ubiquitin #E3ligase #cryoEM @DHornGhetko @LinusHopf Matthias Mann Lab NatureStructMolBiol

Check out our story revealing exciting regulation of the NAD+ biosynthetic enzyme NMNAT1 by the supramolecular CTLH E3 ligase assembly out in Molecular Cell! ➡️cell.com/molecular-cell… Karthik Gottemukkala, D.Sherpa, Arno Alpi Schulman lab Max Planck Institute of Biochemistry (MPIB)

⭐️ Editor's Choice article: Mutations in WDR26 associated with #SkrabanDeardorffsyndrome (#SKDEAS) impair CTLH E3 complex assembly ➡️ doi.org/10.1002/1873-3… Peter J Murray Max Planck Institute of Biochemistry (MPIB)

🔬 Neat discovery in protein degradation. Gray, Schulman, et al labs unveil ZZ1, a prodrug for charged molecular glues that target disease-causing proteins via the GID/CTLH ubiquitin ligase complex. biorxiv.org/content/10.110…

Can we turn the activity of oncogenic kinases against cancer itself? In my postdoc work Stanford University, new in @sciencemagazine, we show exactly that. science.org/doi/10.1126/sc… #ScienceResearch #InducedProximity Sarafan ChEM-H Stanford Cancer Institute Swiss National Science Foundation Stanford Medicine

Principles of paralog-specific degradation engaging the C-degron E3 KLHDC2, now out Springer Nature Nature Communications Awesome collaboration with Richard and Taosheng Chen labs. Structural Biology at St. Jude Children's Hospital Max Planck Institute of Biochemistry (MPIB) St. Jude Research #TPD #PROTAC #SchulmanLab rdcu.be/dWKpF