FDA cleared ß-Amyloids test for Alzheimer’s (Lumipulse): fda.gov/news-events/pr… For age ≥ 55 with cognitive problems (only 32% of those go on to dementia, and this test will help predict that, clearing path for prevention).

Here's where I'm speaking at APA Meeting ● Social Media in Psych (5/18 12-12:45pm, Innovation Zone) ● Rapid Acting Mental Health (5/18, 6-9:00pm, off-site): eventbrite.com/e/ramht-la-202… ● Controversies: Antipsychotics in Depression (5/20 3:45-5:15pm, Petree Hall D) #APAAM25

A peer-led support group for #borderline personality outperformed treatment as usual: pubmed.ncbi.nlm.nih.gov/40315389 The program - designed by people with lived experience and clinicians - focused on stigma, self-compassion, self-care, creative recovery and "building your best life."

Are you at the American Psychiatric Association meeting in LA? Join me at 12 pm for a behind-the-scenes look at the Carlat Psychiatry Podcast. And tonight at Rapid Acting Mental Health (6 pm, off-site register with FriendsRAMHT25): lnkd.in/esh5MA2Q #APAM25

Psilocybin use rising in US, from 2019-23: ● 188% rise in recent use for age > 30 ● 44% rise for age 18-29 ● 723% rise in poison center calls for children (201% for adults) Use now higher than cocaine, LSD, methamphetamine, illegal opioids. ncbi.nlm.nih.gov/pubmed/40258279

Lurasidone for anxiety in bipolar depression? This analysis suggests it helps, more in 20-60 mg range than 80-120 mg. Why? Maybe the higher dose caused akathisia, worsening anxiety: pubmed.ncbi.nlm.nih.gov/40334859 For non-anxious bipolar depression, 40-60 mg is the sweet spot.

Are you at American Psychiatric Association in LA? Hear new data on antipsychotics in #depression today (5/20/25) at 3:45 pm in Petree Hall D. Slides here under "upcoming talks": chrisaikenmd.com/speakerrequest/ Co-presenters: Vikas Gupta, Philip Muskin, Henry Nasrallah, and Ronald Winchel

Doxepin is a tricyclic antidepressant approved for sleep in low doses (3-6 mg). As a hypnotic it: ● Improves early morning awakening ● It is relatively save in elderly ● But only weak effects on initiation insomnia, confirmed by new analysis: pubmed.ncbi.nlm.nih.gov/40229607

New survey of 800 Italian men identifies traits associated with incel (involuntarily celibate) identity: ● Insecure attachment ● Paranoid thinking ● Depression and anxiety pubmed.ncbi.nlm.nih.gov/40226696

Here’s my table on how to pick a benzo…

Preventing PTSD after mass trauma isn’t easy. Well-meaning interventions have backfired, worsening outcomes. So welcome news that this free app - which teaches basic coping skills & sleep restoration - worked: ncbi.nlm.nih.gov/pubmed/40308112 Easy to distribute bouncebacknow.org

Cobenfy is a cholinergic for schizophrenia, but what about other cholinergics (anti-dementia: donepezil, galantamine; anti-nicotine: varenicline)? They didn't help psychosis in new analysis, but one in the pipeline has antipsychotic potential: Emraclidine pubmed.ncbi.nlm.nih.gov/40314158

Update on probioitcs and mood: ● Depression/anxiety linked to inflammatory bacteria ● They improve when anti-inflammatory bacteria are seeded in, whether through fecal transplant or probiotics from: pubmed.ncbi.nlm.nih.gov/40312666 How to use probiotics: chrisaikenmd.com/supplements

Recreational #ketamine use rose 37% in NYC nightclubs from 2017-2024 pubmed.ncbi.nlm.nih.gov/40319543 Rising most among age ≥ 26, college-educated, women, LGBTQ+ People are more comfortable with the drug since its acceptance as an antidepressant, as other studies have found.

When #schizophrenia doesn’t respond to clozapine, augmentation with aripiprazole may help. That's from multiple studies, but none randomized, including this large registry study, which arrived at an optimal dose of 9-16.5 mg for aripiprazole: ncbi.nlm.nih.gov/pubmed/40371869

At-home video app detected Tardive Dyskinesia (TD) better than human raters in a large study. [Sterns AA et al, J Clin Psychiatry 86:3, 9/2025] Even with new #antipsychotics,~25% develop TD with long-term use; diagnosis comes too late. App free at: tdscreen.ai

We have few trials on neurodevelopmental disorders like Prader-Willi Syndrome, so this trial - which finds success with guanfacine for self injury - is a welcome addition. ncbi.nlm.nih.gov/pubmed/40395104 Similar med, clonidine, reduces self injury in borderline personality (PRN).

#Cannabis causes skin problems including • Allergic dermatitis, hives (urticaria) • Rare Stevens-Johnson syndrome, arterial inflammation On balance, may help psoriasis, atopic dermatitis, and acne. From new review: ncbi.nlm.nih.gov/pubmed/40400880