Aetiology of type 2 diabetes: an experimental medicine odyssey Review by Roy Taylor link.springer.com/article/10.100…

Excellent presentation by Dr. Angela Rao on peri-operative GLP1 use before and after bariatric surgery at #ENDO2025! Dimpi Desai

Hypothalamic obesity: from basic mechanisms to clinical perspectives thelancet.com/journals/landi… #ENDO2025

The mechanisms by which ultra-processed foods (UPF) drive obesity, an outstanding review article "the evidence is sufficiently strong to justify immediate public health efforts to reduce UPF consumption." nature.com/articles/s4157…

It's not just genetics. Or just lifestyle. Disease & peak health are both just expressions of an incredibly complicated ongoing physiological mosaic. One must account for genomics, epigenomics, transcriptomics, proteomics, phophoproteomics, and much more. Focusing on

Studies from mice and humans reveal that semaglutide may revert the circulating proteome associated with #MASH to the proteomic pattern observed in healthy individuals reducing #inflammation #fibrosis nature.com/articles/s4159…

The anti-inflammatory power of semaglutide (Ozempic) seen by its normalization to healthy of a 72 protein signature tied to MASH liver disease nature.com/articles/s4159… Nature Medicine

The mixed-meal tolerance test in appetite research 🧵 Topics covered: -Familiarisation/Standardisation 🟰 -Meal stimulus 🥣 -Appetite scales 😋 -Blood sampling 💉 -Blood analyses 🩸 -Data handling 📊 nature.com/articles/s4136… Centre for Nutrition, Exercise and Metabolism

📉 What REALLY happens when you stop anti‑obesity meds? - - - A new meta‑analysis [Wu et al., BMC Medicine, 2025] just mapped the weight regain trajectory after stopping GLP‑1s and other AOMs—and it’s eye‑opening. Key findings: ⏳ First month off: Weight loss continues briefly

🚨First RCT Finds Semaglutide May Slow Biological Aging - - - A 32-week placebo-controlled RCT just delivered the first human evidence that semaglutide may do more than aid weight loss—it may turn back your biological clock. 🧬The Science Epigenetic “aging clocks” track how fast

IMPLEMENTATION OF HOME PARENTERAL NUTRITION (#HPN) Operational recommendations according to the ESPEN guidelines The implementation of HPN follows a structured four-step process to ensure clinical appropriateness, logistical readiness, and patient safety. How to achieve the best

New article in Springer Nature: Body Mass Index Progression, Development of Complications and Healthcare Costs Over 8 Years in UK Individuals Living With Overweight/Obesity Read more: link.springer.com/article/10.100… Luca Busetto

Recovery of β-cell function is the dominant determinant of the remission of prediabetes, akin to its role in remission of diabetes but at an earlier point in the natural history of dysglycaemia thelancet.com/journals/landi… #prediabetes #remission

Incretin hormones—glucagon-like peptide-1 (GLP-1) & glucose-dependent insulinotropic peptide (GIP)—act as a critical link connecting digestion, metabolism, & cardiovascular function, supporting physiological adaptations to nutrient intake thelancet.com/journals/landi… #GLP-1 #GIP

Most people think in terms of short-term weight loss rather than long-term obesity treatment. This is not at all how we think about other chronic conditions like diabetes or high blood pressure.  Great blog post, Ted! Obesity Treatment Is a Marathon, Not a Sprint

Shivering, but not adipose tissue thermogenesis, increases as a function of mean skin temperature in cold-exposed men and women dlvr.it/TMr1ZH

Obesity is a multifactorial, chronic, relapsing, non-communicable disease with an abnormal and/or excessive accumulation of body fat that presents a risk to health. ➡️ A framework for the diagnosis, staging and management of obesity in adults. easo.org/a-new-framewor…

📢The EASO Algorithm for the pharmacological treatment of obesity and its complications has been published in Nature Medicine Developed using rigorous analysis, it provides clinically relevant guidance for personalised medication management. nature.com/articles/s4159… Luca Busetto

Organ-specific imaging biomarkers in obesity care. MRI, CT, PET, & ultrasonography now quantify adiposity, fibrosis, heart & brain changes, and pancreatic dysfunction. Automation & AI enable whole-body MRI segmentation for subcutaneous/visceral fat and muscle, guiding risk

The benefit of Ozempic (semaglutide) for protection from major adverse cardiovascular events (MACE) is independent of weight loss magnitude and baseline adiposity, likely related to the GLP-1 anti-inflammatory effect thelancet.com/journals/lance…