TRACERx Bioinformatics positions available to work on lung cancer evolution and the immune microenvironment in our lab ⁦The Francis Crick Institute⁩ please retweet or apply (or both!) atsv7.wcn.co.uk/search_engine/…

In this review from the Balloux lab and friends @Vehuardo Kathryn Harris we identify major bottlenecks that need to be resolved for WGS to routinely inform clinical intervention and discuss possible solutions. tinyurl.com/y9n25x8s #wgs #diagnostics #amr

Cancer Spreads from Organ Donor to 4 People in 'Extraordinary' Case goo.gl/NJaJNt

BREAKING NEWS The 2018 #NobelPrize in Physiology or Medicine has been awarded jointly to James P. Allison and Tasuku Honjo “for their discovery of cancer therapy by inhibition of negative immune regulation.”

Our research on undifferentiated sarcoma is out today! Have a read to learn more about the genomics underlying this rare tumour type, including highly complex structural rearrangements, hypermutation, near-genome scale haploidy and more! authors.elsevier.com/sd/article/S15…

New paper out today in the Annals of Human Genetics from UCL Genetics Institute Professor David Curtis "Clinical relevance of genome‐wide polygenic score may be less than claimed" tinyurl.com/y6zz97pu #ugi #ucl #polygenic #PRS

If you are interested in rare and fascinating cancers check out our review of the current knowledge of #undifferentiatedsarcoma of soft tissue. Come for shattered chromosomes, near-haploidy, hypermutation and extensive genome doubling! #TheLoneliestCancer authors.elsevier.com/c/1aj5-,Nm41B9…

If you are a data scientist (or just good at coding, machine learning, maths and stats) this is your chance to contribute to #COVID19 critical care! Help doctors find out what they can do to help maximise the survival rate of ICU patients? #datasaveslives

Of g findaphd.com/signups/

Our paper on #ctDNA in #osteosarcoma is out in European Journal of Cancer. Supported by TomPrinceCancerTrust, Bone Cancer Research Trust, Lundbeckfonden. Great collaboration with Neesha, Adrienne Flanagan, Solange De Noon, Stephan Beck, Inga Usher, @orthopoda and others. sciencedirect.com/science/articl…

Super excited to share our opinion article ilaria Malanchi and Francesca Ciccarelli from The Francis Crick Institute on Trends Cell Biology. We aim to add a new perspective to cancer initiation by asking two simple questions: 1) How does a mutant cell gain tumorigenic potential? + cell.com/trends/cell-bi…

Topographies of more than 70 mutational signatures are now available on COSMIC mutational signatures database.

We have expanded our previous method of copy number signatures developed in sarcomas to identify a reference set of pan-cancer copy number signatures. These are available on COSMIC Sanger now! 1/2 nature.com/articles/s4158…

I could not have done this without a Science and Innovation at Cancer Research UK travel grant, nor without the support of @NischalanP to pursue this line of research, or Ludmil Alexandrov for seeing the potential in the method! 2/2 nature.com/articles/s4158…

*Communication is everything* In our latest work we found that histone-H3.3 mutation in the #bone dysregulates the communication between osteoclasts and osteoblasts driving giant cell #tumour of the bone. #celldeathdifferentiation CDD press nature.com/articles/s4141…

Thrilled to share our latest paper on #mutationalsignatures recently published in Cell Genomics 🙌 Thanks so much to everyone that made SigProfilerExtractor a reality, especially Ludmil, Mishu Islam, Mark and Raviteja Vangara. Check it out here: doi.org/10.1016/j.xgen…

Proud and excited to receive a DK Frie Forsk.fond grant for the startup of my translational renal cancer research group at Dept. of Molecular Medicine #renalcancer

#TRACERx Renal: Preview of how 3 multi-center prospective studies + 2 validation cohorts of matched primary metastasis biopsies fm 100 patients with clear-cell renal cell carcinoma provides a comprehensive picture of genetics & evolution of #metastasis bit.ly/2FhcxHR

New package bioconductor.org/packages/curat… provides unrestricted TCGA assays and merged clinical/pathological/specimen data as MultiAssayExperiments containing SummarizedExperiment and RaggedExperiment objects, through ExperimentHub.

New package bioconductor.org/packages/TCGAu… by Marcel Ramos provides a suite of helper functions for checking and manipulating TCGA data including data obtained from the curatedTCGAData experiment package.