The cover featuring our recent fragment binding study is now out @ ACS Chem Bio: pubs.acs.org/toc/acbcct/20/… Huge thanks to the talented Ivo Kabelka from CarlssonLab for creating this beautiful cover art.

Thanks for highlighting our paper! nature.com/articles/s4146…

mynewsdesk.com/uu/pressreleas…

Curious about the new trends in #GPCR #drug discover? See our new analysis review out today in Nature Reviews Drug Discovery. doi.org/10.1038/s415... 36% (n=516) of all approved drugs act on 121 GPCRs targets.

Identifying ligands for therapeutic targets among billions of compounds is challenging! Can we search ultra-large chemical libraries more efficiently? Yes! Read about our docking/ML approach: nature.com/articles/s4358…

📢Andreas Luttens, CarlssonLab and colleagues develop an efficient method to screen libraries containing billions of compounds. @UU_University, SciLifeLab, Cancerfonden, Vetenskapsrådet, KAW, European Research Council (ERC), Enamine Ltd 🇺🇦, Broad Institute, MIT IMES nature.com/articles/s4358…

Wow,wow,wow!!

In our latest paper we share our machine learning protocol to screen billions of compounds for novel ligands with tailored properties. SciLifeLab, @UU_University, USC, KAW nature.com/articles/s4358…

scilifelab.se/news/supercomp…

Glad to share our new article on the #hydrophobic #collapse of #PROTACs ! pubs.acs.org/doi/10.1021/ac…

Sign up for the GPCR workshop at AstraZeneca (Gothenburg), 6th of May! Please share this information! Sign up here: insingulo.com/registration

AI meets rapid antiviral design. We used EvoBind to design a cyclic peptide HIV-1 inhibitor in a single shot to a novel interface, directly from sequence. Low micromolar activity, no toxicity, no structural data needed. biorxiv.org/content/10.110…

Allosteric modulators of D2 - we're coming for you! Read our latest paper on where allosteric modulators of the D2 dopamine receptors bind - new strategy for treating Parkinson's disease? pubs.acs.org/doi/10.1021/ac…

Article: Identification of a Lipid-Exposed Extrahelical Binding Site for Positive Allosteric Modulators of the Dopamine D2 Receptor #research supported by Knut and Alice Wallenberg Foundation #KAW100 #Parkinsons #Dopamine CarlssonLab ACS Publications tinyurl.com/ycxdkcum

Lab BBQ, including chicken feet and Bánh mì.

Biased adrenergic agonists – a novel treatment for diabetes! Amazing paper in Cell from a project led by Tore Bengtsson (Stockholm Uni) and Shane Wright (Karolinska Inst): cell.com/cell/fulltext/… Great work by my student Nour Kahlous, who performed simulations of the compounds.

Just published in PNAS: Our structure-based virtual screening approach to identify allosteric modulators of G protein-coupled receptors (GPCRs): pnas.org/doi/10.1073/pn…. Great collaboration between Monash University and Uppsala universitet.

Our recent work was highlighted in Nature Reviews Drug Discovery ! Read more at: nature.com/articles/d4157…