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📢 Late breaking #2002 ➡️In ICI-induced arthritis, patients (n=100) report worsened pain, fatigue, & physical function vs population norms. ➡️High disease activity worsens symptoms #acr24 Dr. John Cush Johns Hopkins Rheumatology

📢Late-breaking #2003 🔑 Cappelli et al Johns Hopkins Rheumatology finds hip OA is NOT a significant risk factor for #ICI-IA 🔴#ICI-IA linked to lower mortality #ACR24 #ACRBest Dr. John Cush

Late-Breaking Abstract L07 The CLASS Project introduces new global classification criteria for Anti-Synthetase Syndrome (ASSD). Using the gold standard dataset, the key findings were: ✅ Definite ASSD: Sensitivity 94.3%, Specificity 99.7% ✅ Probable ASSD: Sensitivity 97.5%,

The 🫀is muscle‼️ 💥From the maestro herself Julie J. Paik underscores why cardiac involvement in myositis can't be overlooked. 🔥Crucial insights with major implications for patient care and outcomes #acr24 Dr. John Cush Johns Hopkins Medicine Johns Hopkins Rheumatology youtube.com/watch?v=8ckDPf…

#2259 💊 Anti-Obesity Meds in RA 📊 152 RA patients on semaglutide/tirzepatide 🔑 Findings 💥Significant ⬇️weight, BMI, ESR, CRP, lipids, pain VAS 💥Improved CVD risk ⛔ 15% GI side effects, 27% discontinued 🔎Study of impact on RA outcomes needed #ACR24 Dr. John Cush #ACRBest

📢Late-breaking #2259 ⚖️ Weight trends in #PsA ➡️IL-17i, IL-23i, & csDMARDs linked to weight loss, while TNFi & IL-12/23i associated with weight gain ➡️Apremilast shows a weight loss trend. Age, sex, comorbidities play a role 🔑Insights for personalized care! #acr24 Dr. John Cush

I highlight important insights into changing trends in RA treatment by Jeffrey Sparks MD MMSc et al. ⬆️ bDMARD and tsDMARD use ⚖️ Important to balance innovation with evidence base

#2222 📊 New data on #RA-ILD: 🔴In early RA, ILD prevalence hits 21.4% after 10 years, with 8.2% cumulative incidence at 5 years (IR 14.9/1000 PY). 🔴ILD often precedes or coincides with RA onset. 🔴NSIP > UIP 🔴airway involvement less common than expected. #acr24 Dr. John Cush

Quote of the day. “Time is kidney” Maria Dall’Era MD, UCSF at the ACR SLE guidelines for management of lupus nephritis Dr. John Cush #ACR24

#2286🔬Certolizumab Pegol (CZP) in High RF RA 📊Pooled analysis;N=1180 💥PBO: High RF=more radiographic progression v low RF (Wk24 6.5 v 2.8%,Wk52 17.6 v 10.4%) 💥CZP: min. progression regardless of RF (Wk24 0 v 1.1%;Wk52 5.3 v 3.1%) #ACR24 Dr. John Cush

One of the reasons why it is so difficult to maintain weight loss is because adipose issue retains an epigenetic memory of obesity after weight loss. nature.com/articles/s4158…

Great project by @kekuchinad to evaluate how PFTs bias our assessment and contribute to disparities Caoilfhionn Connolly Johns Hopkins Rheumatology Hopkins Bayview IM Residency Dr. John Cush #ACR24 youtu.be/wruVhEKJIqQ?si…

Mortality Risk After Stopping Glucocorticosteroids (GC) in RA. In a study of 28,078 RA patients: Mortality risk from CVD ↑ 7.5%/year of GC use; ↓ 1.3%/year after stopping. Mortality risk from infections ↑ 6.8%/year of GC use; ↓ 4.9%/year after stopping. Risks normalize 1.5–10

ACR24 take homes ➡️#Inflammatory #myositis #Upadacitinib improved MDA5 ILD #Baricitinib 4mg/d good in myositis delayed start #RCT #Tofacitinb ➡️help for skin, calcinosis, rash in case series ➡️RCT ongoing JAKi is ‘jacked’ in muscles 💪🏿 #ACR24 Dr. John Cush American College of Rheumatology 1731 0348

🔥Movement 🟰Medicine ‼️ Positive impact of activity across all ages in study of >2 million people ➕Even small steps have positive impact

Dreaming of Relief: The Importance of Sleep in Lupus and Rheumatoid Arthritis Sleep is crucial for managing inflammation and health. In rheumatic diseases like lupus and RA, disrupted sleep is common and can worsen symptoms and disease progression. Experts stress the importance

ACR24 PsA Topic Panel: Advancing Care for Psoriatic Arthritis x.com/i/broadcasts/1…

Check out our topic panel where we discuss the most exciting abstracts on #PsA at #ACR24 led by Catherine Bakewell Antoni Chan MD (Prof) Caoilfhionn Connolly #ArtieKavanaugh

New online! An update on autoantibodies in the idiopathic inflammatory myopathies go.nature.com/4g2IF4x

ACR24 PsA Topic Panel Advancing Care for Psoriatic Arthritis Tune in for an engaging discussion at the ACR Annual Meeting! This expert panel will explore the latest breakthroughs and trends in Psoriatic Arthritis(PsA) research and management, providing actionable insights for