Today in @Science_Magazine we report the laboratory evolution of compact degrons that enable targeted protein degradation triggered by an otherwise-inert small molecule, a multidisciplinary study that integrates organic chemistry, molecular glues, protein evolution, genome

We’re #hiring! Multiple #postdoc positions will be available in my lab to study DNA damage response signalling from June onwards. Get in touch with your CV if interested. Please RT!

A postdoc position is available to join the group as part of an international consortium to address bottlenecks in early detection of ovarian cancer. Have a look here to find out more and apply if you're interested: jobs.manchester.ac.uk/Job/JobDetail?…

Don't miss out! Applications for this studentship end in a week. DM me if you are interested.

📢New #review on DUBs and ULPs in genome stability now available and open access in Biochemical Journal #Biochemj Portland Press. We try to give an overview of Ub/UBL erasers in DNA damage response pathways and the mechanisms involved. Check it out! portlandpress.com/biochemj/artic…

Interested in early detection of #ovarian cancer and looking for a highly collaborative project? Look no further than the #postdoc position now open in the Genome Stability Lab group to identify Novel Early Markers for Ovarian cancer (NEMO). Apply and more detail: jobs.manchester.ac.uk/Job/JobDetail?…

Check out this project if you're interested in interdisciplinary research addressing how ubiquitin-like proteins regulate cell signalling in the context of the DNA damage response and cancer findaphd.com/phds/project/e…

Congratulations to Dr Zac Sandy for passing his viva today 🎓🎉🎊🍾🥂 A big thank you to the examiners Drs Stefan Meyer and Alex Garvin for their help, time and excellent examining, and thank you also to Kiran Batta for jumping in as independent chair in the last minute!

Dear all, here is a new paper describing some of Sophie’s lovely PhD work on KU80-binding motifs (KBMs) and replication stress. It’s very interesting (he said, totally unbiased)! url.uk.m.mimecastprotect.com/s/cn1bCEx6AFDW…

Fantastic - congratulations!

Dr Melanie Seaton, PhD 🎓 Today was the perfect graduation day and I was so lucky to celebrate this frankly massive achievement with my wonderful family, partner and friends. I’m so so grateful to you all. On to the next adventure!! 💖🎓💫

Lots of engaging questions, insights, networking, and candid sharing of career experiences from all the fantastic speakers at the Early Career Symposium! Thankful to Biochemical Society for organising! #careers #ECR #BiochemEvent

Another chance to join us at Birmingham. This time open also to ECRs and junior independent researchers. Genome biology is one of the priority areas (as is cancer and RNA biology). Have a look 😀. Get in touch 😀

Check out this beautiful study from Pei Yee, now published in Journal of Cell Biology!

Happy to see our collaborative paper with Cyrus Vaziri’s lab demonstrating that RNF168 is recruited to damaged replication forks via a degenerative PIP box and its MIU1 ubiquitin binding domain is finally out in Nucleic Acids Res : academic.oup.com/nar/advance-ar…

Applications are open for our Clinical & Non-Clinical PhD projects! 🧬 Access state-of-the art facilities 🌍 Learn from world-leading academics 🐝 Study in the buzzing city of Manchester 📆 Deadline: 15th November Explore our current projects: crukcentre.manchester.ac.uk/study/research…

👏 We're delighted to have been awarded £5.9m from Science and Innovation at Cancer Research UK to develop new radiotherapy technologies and techniques over the next five years. Read more about the new funding: mcrc.manchester.ac.uk/manchester-sci… The Christie NHS | The University of Manchester

APEX peroxidase is a versatile tool for proximity labeling and electron microscopy (EM) but its requirement for toxic H2O2 is a liability. We now report LaccID, a multicopper oxidase evolved from an ancestral fungal laccase that oxidizes aromatic substrates using non-toxic O2

Closing soon - ACED Non-Clinical PhD Studentship. 🚨 💰Fully-funded for 4 years 👩‍🔬Learn from leading cancer researchers 🏥 Rotate your training across various ACED Centres 📅 Deadline: Monday 4 November 🔗 Apply: ow.ly/WGIW50TtugI

If you think the next big idea in your field will come from inside the field, you're probably wrong.