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New Paper from I03 in Biochemistry doi.org/10.1021/acs.bi… (pdbe.org/8RLY)

Our lab's latest paper. This is so exciting!! This paper is literally 10 years in the making, and it is bringing me great joy to see it published. Also the figures in it are 🔥so you should give it a read! x.com/biophyskrys/st…

"In this work we investigate the intracellular activation of the dithiolopyrrolones and their resistance mechanisms in bacteria." From Li and colleagues UNC-Chapel Hill Chemistry pubs.acs.org/doi/10.1021/ac… #naturalproducts #resistance #prodrug #redox

"These developments provide a promising solution for unlocking the vast knowledge concealed within the protein structure universe and suggest that we have entered a new era of protein structuromics." Viewpoint by Nie & colleagues @ Jiangnan U pubs.acs.org/doi/10.1021/ac… #AI #tbt

Finding RNA features: Rakheja et al report "TRIPinRNA," an in silico platform that searches for triplexes across the transcriptome, and validate several hits, including a structure previously thought to be unstable. pubs.acs.org/doi/10.1021/ac… #RNA CSIR-IGIB AcSIR

⏰ DEADLINE APPROACHING! ⏰ Submit by December 31! Biased Signaling is an upcoming Special Issue in Biochemistry organized by Executive Editor Bryan Roth (BryanRoth) Learn more here and get your research seen by the global #Biochemistry community ➡ go.acs.org/c15

Excision repair: Kirillov et al report the 1.05 Å structure of S. aureus endonuclease IV, revealing Fe atoms instead of Zn & unexpected coordination details. pubs.acs.org/doi/10.1021/ac… #bioinorganic Hebrew University Diamond Light Source University of Michigan НЦБ University of Exeter Faculty of Medicine - The Hebrew University L.N. Gumilyov Eurasian National University

CG17192 is a phospholipase that regulates signalling #lipids in the Drosophila gut upon infection buff.ly/4iT9ABv (Biochemistry)

Inducing expression of cryptic gene clusters can be challenging. Lee et al test two Burkholderia species using high-throughput elicitor screening, finding new molecules with unusual modifications. pubs.acs.org/doi/10.1021/ac… Princeton Chemistry Princeton MolBio Pusan National University #biosynthesis

Glumatic peptidases play roles in pathogenesis, celiac disease and cancer. Oda KIT-kyoto and Wlodawer National Cancer Institute #review the six subfamilies, exploring common features among diverse functions that could drive drug discovery. pubs.acs.org/doi/10.1021/ac… #tbt #peptidase #plant

Antivirals: The protein G3BP1 helps to block viral replication, but viruses also have defenses against G3BP1. Dhaka et al IIT Roorkee identify new details of this defense and show small molecules that block protein interactions have antiviral efficacy. pubs.acs.org/doi/10.1021/ac…

Excited to start 2025 with our recently accepted "Mitochondrial Sorting and Assembly Machinery: Chaperoning a Moonlighting Role? pubs.acs.org/doi/full/10.10… " Congratulations Roshika and Deepsikha!👏 Biochemistry SERB Department of Biotechnology DBT/WT India Alliance Gobardhan Das, Immunologist IISER Bhopal

"we propose that TRF2 can be “auto-regulated” through the G-quadruplex formed by its own gene sequence." Xu and Wang examine a possible feedback mechanism for gene regulation that may extend beyond TRF2/telomeres. pubs.acs.org/doi/10.1021/ac… #quadruplex #telomere #generegulation

New issue! 📣 Read up on biased signaling, RNA editing, gut microbes, antibiotics and more! pubs.acs.org/toc/bichaw/64/1 Cover art: Lee & Rauscher University of Toronto explore flexible loops in the main protease of SARS-CoV-2, with implications for drug discovery. pubs.acs.org/doi/10.1021/ac…

The latest Link lab paper is out Biochemistry!: doi.org/10.1021/acs.bi… This work, led by Angela Zhu, focuses on the cysimiditides, a new subfamily of #RiPPs. The cysimiditides include a tetracysteine motif that coordinates a zinc ion and a single aspartimide moiety.

Reviews roundup: In 2024, Biochemistry authors explored GPCRs, antibiotics, and tumor hallmarks, examined PET recycling and telomere motifs, and much more. Catch up with all Reviews here: go.acs.org/c8A And find Perspectives here: go.acs.org/c8B

"Metals in Motion: Understanding Labile Metal Pools in Bacteria" Biochemistry This is an insightful review on cellular metal physiology by John D. Helmann with interesting historical context and a beautiful dedication section🙏 pubs.acs.org/doi/full/10.10…

Happy to have this cover designed by local artist Sammie Bruner associated with our recent publication "Mechanism of Catalysis and Substrate Binding of Epoxyqueuosine" (10.1021/acs.biochem.4c00524). ACS for Authors #MyACSCover

New issue! 📣 Read up on antibiotics, moonlighting, arrestin-1, the apoptosome, and more! pubs.acs.org/toc/bichaw/64/2 Cover art: Bruner Lab and colleagues UF Chemistry Massachusetts Institute of Technology (MIT) reveal details of the final step of queuosine biosynthesis in modified #tRNA. pubs.acs.org/doi/10.1021/ac…