Interested in single cell genomics but need help getting started? Check out my lab's Single Cell Genomics Day on March 4. Talks will feature recent exciting computational and experimental advances and will be livestreamed at satijalab.org/scgd. Please RT/spread the word!

Today is #DarwinDay! 🧬 We spoke to the incoming Director of our Centre for Evolution and #Cancer about his research, how he's inspired by Charles Darwin and the potential of harnessing evolutionary theories to defeat cancer: icr.ac.uk/blogs/science-… #CancerEvolution

We are hiring! jobs.icr.ac.uk/vacancies/213/…

How do we infer clonal dynamics in human tissue, when we typically only have access to a single snapshot of that tissue’s evolutionary history? With lineage tracing markers and maths! Our review out now doi.org/10.1002/path.5… Trevor Graham Nicholas Wright

What a tour de force! Fantastic and timely analysis of a major prostate cancer subtype.

🚨🚨Last two weeks to apply for a postdoc position in our lab at the The ICR Centre for Evolution and Cancer, ICR funded by the Cancer Research UK 🚨🚨 jobs.icr.ac.uk/vacancies/213/…

On behalf of my co-authors I am delighted to share our report published in Clinical Cancer Research, Assessment of Androgen Receptor splice variant-7 as a biomarker of clinical response in castration-sensitive prostate cancer aacrjournals.org/clincancerres/… Adam Sharp 1/10

Fantastic study by the lab of our Cancer Research UK Convergence Science Centre director Behrens lab and colleagues!

💥Are you interested in cancer clonal dynamics and resistance to treatments? We have 2 postdoc positions open at the The ICR Centre for Evolution and Cancer, ICR to study prostate cancer evolution at single-cell resolution 💥 Apply here jobs.icr.ac.uk/vacancies/335/…

Most people at #BCB22 used high-throughput DNA or RNA seq at the centre of their research. But lots of other features define cancer: foremost PROTEINS! Also pH, mechanobiology, oxygen & glucose availability, host factors etc etc. Are we stuck looking under the lamppost? #BCB22_Qs

Check out our paper just published in @nature showing that melanoma growth and metastatic dissemination are fuelled by limited and distinct cancer cell populations. nature.com/articles/s4158… work led by AMAZING Panagiotis (Takis) Karras (1/3)

Cancers are genetic/phenotypic polymorphs, a quasispecies of cellular entities that dances around immune system attacks. We detail an approach to dissect the patchwork behavior of tumors using deep spatial profiling alongside a novel barcoding strategy. sciencedirect.com/science/articl…

(1/8) New Preprint! Would you like to design synthetic cis-regulatory DNA for your preferred application? Look no further! We have made it simple and robust! biorxiv.org/content/10.110…

Please RT 🎉🎉🎉 Join us to understand how the ribosome dictates cell identity, focusing on hematopoiesis and leukemia. We're studying cell identity in-vivo and developing new and amazing tools! Fully funded European Research Council (ERC) positions - postdocs and PhDs. nachmanilab.com

We see and feel the loss of talented EU students in postgraduate research (including postdocs). The high overseas student fees issue is somewhat mirrored for PhD students too. theguardian.com/education/2023…

Does immune selection influences tumor antigenicity and impact response to checkpoint inhibitors? Yes! Our latest publication sheds new light on the complex relationship between cancer and the immune system. #immunotherapy #Cancer The ICR Centre for Evolution and Cancer, ICR rb.gy/4fqzhm

Join one of the world's leading centres for cancer #DrugDiscovery! We're making a significant investment in our Division of #CancerTherapeutics with the appointment of five new senior Faculty. Find out more about the new roles here ⬇ icr.ac.uk/media/docs/def… #ScienceJob

Starting day 3 of #TMFOCE in sunny #Rimini (admittedly, a bit less “fresh” this morning..) with GuccioneLab insights on fetal-like phenotypes in CRC 🤩. Perk of Ernesto’s intro, a sneak peak of co-organiser @MagnaniLab_ICR and his past interests (on the left of the pic) 😉🤣

New #vacancy for a Lab Manager to support the 11 labs across our Division of Molecular Pathology The ICR, which includes our Centre for Evolution and Cancer Centre for Evolution and Cancer, ICR. Details here: jobs.icr.ac.uk/vacancies/961/… JonesLabICR Kamil R Kranc Alejandra Bruna Lab Bezzi Lab Paul Huang Lab

Does cancer #evolution & intra-tumour heterogeneity predict long-term relapse? We tested the evolutionary paradigm in prostate cancer clinical trials with long follow-up, combining genomics with digital histopathology: nature.com/articles/s4301…