☕️NEW: Ali et al. show that, during #heatshock, aggregation-prone orphan #RibosomalProteins form #nucleolar-associated #condensates that are kept in a liquid-like and reusable state through #Hsp70 and its co-#chaperones. rdcu.be/dptxJ nature.com/articles/s4155…

Our structures of the #cardiac #sarcomere are now published in nature! With #teamtomo at Stefan Raunser lab, we've used #CryoET to unveil how #myosin and #actin filaments arrange in #muscle relaxed with #mavacamten. Great collaboration with Gautel Lab! doi.org/10.1038/s41586… 🧵

☕️NEW: Mukherjee Lab, Walter & co show that the secreted #Legionella protein SidI is a #tRNA mimic and #glycosyltransferase that inhibits #HostCell translation by inducing #ribosome collisions & #ribotoxic stress response. UC San Francisco rdcu.be/dp6gT nature.com/articles/s4155…

Check out the latest pre-print from the Green Lab and Jingdong Cheng labs! Here, my colleagues propose that LARP1 binds to non-translating ribosomes to regulate the translation of mRNAs containing 5’TOP motifs such as ribosomal proteins.

👋Our November issue's live! Cover: #chaperone #condensates 👉🏿Read: #MitochondrialMetabolism #neuron #mechanotransduction #PhaseSeparation #lipidhomeostasis #ribotoxic stress #genomestability #senescence #MitochondriaTransfer #DEI... & more! nature.com/ncb/volumes/25…

We are on Cover, #Chaperone #Condensates. Framing Heat Shock response as Condensostasis rather than Proteotoxic.

amazing integrative study of coronavirus NL63, with cryoET, sub-tomogram classification and averaging (chiulab stanford, SLAC National Accelerator Laboratory), glycan profiling by mass spec (Lance Wells), MD (Abhishek Singharoy), and functional infectivity assays (Jing Jin) rdcu.be/dqvKa

Need a quiet space to read, relax or work? Visit the Arley D. Cathey Learning Center in this "study with me" style video. High-vaulted stone ceilings bring a sense of grandeur to your study session, with a carefully curated mix of classical music. youtu.be/qupg8_2vFgc

PRC2 is reported to bind RNA. Yet, genetic experiments have raised serious questions about their functional relevance. Our paper revisits the biochemical evidence supporting widespread PRC2-RNA interactions and finds that many of these do not occur in vivo.

Macromolecular condensation organizes nucleolar sub-phases to set up a pH gradient: Cell cell.com/cell/fulltext/…

Online Now: Nucleolar stress caused by arginine-rich peptides triggers a ribosomopathy and accelerates aging in mice dlvr.it/T4cJ7k

Design principles to tailor Hsp104 therapeutics biorxiv.org/content/10.110…

Our recent work (led by sammy keyboard) on evolution of biomolecular condensation is now highlighted as a featured article (and is open access) 🔬 nature.com/collections/bb… nature.com/articles/s4146…

☕️In this issue: A Comment on #VolumeElectronMicroscopy, standards in sample preparation and image acquisition for enhanced reproducibility and data reuse. 👉🏼rdcu.be/dGMhZ nature.com/articles/s4155…

Hey #condensate enthusiasts, We just wrote a perspective piece describing biomolecular condensation as a preservation mechanism for orphan proteins during environmental changes. Preserve or destroy: Orphan protein proteostasis and the heat shock response rupress.org/jcb/article/22…

MOSAIC lattice light sheet xy projection over 2+ hrs in human retinal pigment epithelial cells of endoplasmic reticulum remodeling (cyan) and transport of vesicles (yellow) containing β4-galactosyltransferase....

Happy to share our community note published in Nature Communications. In this 14-page article (34 authors from 9 countries), we discuss current practices in biomolecular phase separation and hope it will be useful to the biomolecular condensate community. nature.com/articles/s4146…

Excited to share our new work "Dissecting the Cdc37 Co-chaperone Code: Functional Roles in Chaperone-Mediated Stress Adaptation" in press at the Journal of Biological Chemistry jbc.org/article/S0021-… 🔥🔥🔥

What a terrific recognition of our research field! Dirk Görlich (Max Planck Institute Göttingen) & Steven McKnight (UT Southwestern) received the Lasker Award for their work on low-complexity domains & their phase separation. Read the perspective in PNAS: pnas.org/doi/epdf/10.10…

🔬❄️ The new Krios 5 from ⁦Microscopy & Spectroscopy⁩ is looking sharp in its new Midwest Center for Cryo-ET lab ⁦UW–Madison Biochem⁩ UW–Madison CALS⁩ ⁦UW–Madison⁩! Increasing #cryoEM #teamtomo access for bioscience researchers with support from ⁦NIH Common Fund⁩ ❄️🔬