New paper by Anders J. Skanderup Guanhua Peter Zhu A*STAR Genome Institute of Singapore (A*STAR GIS) shows that nucleosome-dependent degradation and 6 regulatory regions are predictive of #circulating #tumour #DNA burden throughout #cancer #progression #CancerResearch Cancer at Nature Portfolio go.nature.com/3uSbKYl

Excited that our paper is online! Highlights how pervasive lineage transition occurs at a transcriptomic level in T790M neg resistance, suggesting the potential for tissue-based integrative analysis to forecast resistance trajectories in EGFR M+ NSCLC. clincancerres.aacrjournals.org/content/early/…

Collaboration with Sjoerd van Hagen, Sander Rodenburg and Elena Garcia Lara The Hyve and Augustin Luna Augustin Luna - more to come as CPTAC enters its next phase. Go proteomics in cancer profiling!

Wonderful portal that enables exploration of the phenomenal Hartwig metastatic cancer WGS/RNAseq cohort.

Effective drug combinations in breast, colon and pancreatic cancer cells. 2025 drug combinations vs 125 cancer cell lines 😮nature.com/articles/s4158…

Those signatures that were reported in that amazing 18k WGS analysis paper in Science yesterday? They can all be browsed on the amazing Signal resource portal! signal.mutationalsignatures.com. 😎

Excited to share our new study and resource on tumor metabolism with Neha Rohatgi A*STAR Genome Institute of Singapore (A*STAR GIS). Using tumor transcriptome deconvolution, we identify metabolic differences of cancer and stromal cells inside tumors. Some expected and unexpected findings ... doi.org/10.1016/j.celr…

‼️ OUT TODAY Nature Genetics 📰 Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer 🧑🏿‍🤝‍🧑🏼 Iain Tan, NCCS/GIS/Duke-NUS/STCC Shyam Prabhakar Lab A*STAR Genome Institute of Singapore (A*STAR GIS) and colleagues 👇🏿 go.nature.com/3bI7ZA8

VarNet, a weakly supervised #deeplearning model for somatic #VariantCalling in cancer that does not require human-engineered features or heuristic filters #CancerResearch by Anders J. Skanderup Kiran Chari et al. go.nature.com/3opGfDM

Our recent preprint trying to explore the tricky question of “blood microbiome”! Great work by an amazing intern in the lab Cedric C.S. Tan guided by Minghao Chia biorxiv.org/content/10.110…

To update the classification system for #colorectal #cancer, the team analysed 373,000 #singlecells from 141 #tumour samples collected frm 63 patients in SG, BE, S KR. Read: clinicalresearchnewsonline.com/news/2022/08/1…

1 of the deadliest cancers with diverse etiological factors worldwide. We found unprecedented genomic diff. segregating distinctively across ethnicities & stressed the importance of differential disease biology & management in HCC across ethnicities. thno.org/v12p4703.htm

Singapore scientists develop AI-based method to identify cancer mutations buff.ly/3pSJLaf

#Fluoxetine (#Prozac) changes so many genes in so many brain regions. Mechanism(s) of action are dizzyingly complex, but some promising themes emerge👇. Long-term collab with Meaneylab et al. Large integrative omics study heroically led by Nirmala Rayan. A*STAR Genome Institute of Singapore (A*STAR GIS) #depression

Today our important study on air pollutants in the promotion of lung cancer has been published in nature led by Will Hill Emilia Lim Clare Weeden Swanton Lab ...Thread below🧵nature.com/articles/s4158…

PUREE is a weakly supervised machine learning algorithm that can accurately infer tumor purity from bulk tumor gene expression data: doi.org/10.1038/s42003… Anders J. Skanderup, Egor Revkov

Go cBioPortal ! Lots of new features for easy analytic access to cancer genomics, proteomics and more. Make your own discoveries on community-provided cancer data and analysis tools.

Can AI help predict pancreatic cancer earlier? nature.com/articles/s4159… and hms.harvard.edu/news

Really clever approach to help understand the impact of broad copy number changes: Cancer aneuploidies are shaped primarily by effects on tumour fitness nature.com/articles/s4158…

✨Highlighting a Cancer Discovery Special Issue Commentary for #AACR24: Precision Endpoints for Contemporary Precision Oncology Trials - by Regina Hoo, Kevin Chua, Pankaj Kumar Panda, Anders J. Skanderup, & Daniel Tan doi.org/10.1158/2159-8…