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Come join us! Our Biochem Dept is a fabulous place to build a career! Top-notch science, supportive colleagues, world-class facilities, and exceptional trainees! Pls help spread the word. Feel free to ping me with Qs, I am the search co-chair

Another great Heiko Lickert and Fabian Theis cooperation. Kudos to Karin Hrovatin as main driver with great help of Aimée Bastidas Ponce, Mostafa Bakhti, Luke Zappia, Anika Boettcher , @marenbuettner , Ciro Salinno and Adriana Migliorini

To get a quick sneak-peak into our recent mouse islet atlas (MIA) paper, here is the research briefing: nature.com/articles/s4225….

Many immune evasion strategies to protect SC-islets from transplantation rejection employ CD47 overexpression, while this new paper suggests CD47 negatively impacts beta cell function. Clearly many of such strategies warrant more detailed studies. science.org/doi/10.1126/sc…

Our recent review article describing "Mitochondrial regulation in human pluripotent stem cells during reprogramming and β cell differentiation " is now out. Check it out here below 👇 #iPSCs #SCIslets #Diabetes #StemCells #CellTherapy frontiersin.org/articles/10.33…

Our latest work on the function of NEUROD2 during human endocrinogenesis. Led by Perla Cota and Lama Saber. Thanks to Heiko Lickert Changying Jing (Diana) Aimée Bastidas Ponce and others involved. frontiersin.org/articles/10.33…

1/ Thrilled to share our latest research on the role of insulin in human endocrinogenesis, led by Perla Cota. Thanks to Heiko Lickert Özüm Şehnaz Günel Çalışkan Natalie Krahmer Aimée Bastidas Ponce Changying Jing (Diana) Lama Saber and others involved. sciencedirect.com/science/articl…

Excited to share our new manuscript ⁦Molecular Metabolism⁩ This study led by ⁦CAMB Graduate Group⁩ graduate student Libby Nunn explores the potential of activin type II receptor blockade to maintain muscle mass and enhance fat loss during GLP1RA in obese mice sciencedirect.com/science/articl…

More β cell heterogeneity, with RRβs as a subpopulation of β cells that make a disproportionally large contribution to biphasic GSIS from mouse #islets Nature Metabolism #insulin #diabetes nature.com/articles/s4225…

Insightful work from our Helmholtz Diabetes Center (HDC) colleagues Heiko Lickert Timo Müller Matthias Tschöp et al corroborating Inceptor as key mediator of IGF1R & INSR signaling in diet induced obesity - validating Inceptor as promising therapeutic target 👍🎇🎉nature.com/articles/s4225…

Extremely happy to see this great cooperation with Timo Müller and Matthias Tschöp published in Nature Metabolism. The Inceptor story continues and stay tuned, as we also found a ligand 😉 hopefully published very soon as well…

Terrific work!!!

.... and following up on my previous post, I am pleased to share our article online today The Lancet Diabetes & Endocrinology Full text available (next 50 days) via this link through Elsevier url.au.m.mimecastprotect.com/s/fgPkCyojKztW…

Excellent talk by Timo Müller at the American Diabetes Association - DiabetesPro conference!

🚀Excited to share our latest work in Heiko Lickert lab: "Resolving human α vs β cell fate allocation for generating stem cell-derived islets." Thanks to the amazing contributions from Lama Saber, Eunike Setyono, and Tobias Greisle! Read more here: doi.org/10.1101/2024.0… 1/

Proteomic predictors of individualized nutrient-specific insulin secre... sciencedirect.com/science/articl… is the latest work from star fellow (and current faculty job hunter) Dr. Jelena Kolic Jelena Kolic.

NNC2215, an insulin conjugate with a glucose-binding macrocycle and a glucoside, creates a glucose-sensitive switch that reversibly responds to ambient glucose levels, potentially reducing hypoglycaemia risk in diabetes treatment. nature.com/articles/s4158… #NBThighlight

Our new paper, "NK2R control of energy expenditure and feeding to treat metabolic diseases," is out today in nature. Here we identify a single receptor that can both peripherally increase energy expenditure and centrally suppress appetite. nature.com/articles/s4158… 1/12 🧵👇

Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”. doi.org/10.1038/s42255… A tremendous collaborative effort led by Johanna Siehler, Sára Bileková and other members of the Heiko Lickert lab.

Exciting study by Amanda Andersson Rolf et al: In vitro expansion of a human fetal #pancreas #stemcell that generates all three pancreatic cell lineages”. cell.com/cell/fulltext/… 1/