Great work by a talented and tireless PhD student. Keep a look out for when IrsaS is on the job market later this year!

nature.com/articles/s4146… Just out! Significant additions to the preprint biorxiv.org/cgi/content/sh… are the separation of coexisting motor-head conformations and improved resolution (2.7-3.9 Å now). Matthieu Benoit HernandoSosa SEMC cryoEM Papers #microtubule #kinesin

nature.com/articles/s4146…

Brief update on some exciting progress on #AlphaFold! We’ve been heads down working flat out on our full methods paper (currently under review) with accompanying open source code and on providing broad free access to AlphaFold for the scientific community. More very soon!

Today with EMBL-EBI, we're launching the #AlphaFold Protein Structure Database, which offers the most complete and accurate picture of the human proteome, doubling humanity’s accumulated knowledge of high-accuracy human protein structures - for free: dpmd.ai/alphafolddb 1/

This is what tenacity looks like 👉🏼 ⁦IrsaS⁩ . Congratulations and best wishes for your bright future, Dr. Shoukat 👏👏👏

Let's start the new year with the CanFunNet Seminar series! Featuring @jessiemacalpine and Jonathan Cazabonne 🍄🧬 presenting their research on January 20 at 2pm EST. DM for details #CFNSeminarSeries

Kinesin-8-specific loop-2 controls the dual activities of the motor domain according to tubulin protofilament shape biorxiv.org/cgi/content/sh… #bioRxiv

Our new manuscript with SosaLab and Matthieu Benoit in bioRxiv shows the structural basis of motility and microtubule depolymerization by kinesin-8, and how it alternates between these activities!

Kinesin-8s are motile #microtubule depolymerases. Matthieu Benoit and SosaLab in collaboration with Queen's University researchers Byron Hunter, Caitlin Doubleday and Daria Trofimova provide a library of high-resolution structures that show how they function. dlvr.it/SKrQYT

If you want to understand hydrolysis, you need to see water molecules! 6 #cryoEM structures of #actin filaments at ~2.2 Å explain filament assembly and aging: biorxiv.org/cgi/content/sh… Thanks to Wout Oosterheert & alexander.belyy, Björn, Sabrina MPI Dortmund Max Planck Society

Bound nucleotide can control the dynamic architecture of monomeric actin | Nature Structural & Molecular Biology nature.com/articles/s4159…

A paper published in Nature Methods presents ColabFold: a free and accessible platform for protein folding that provides accelerated prediction of protein structures and complexes using AlphaFold2 or RoseTTAFold. go.nature.com/3wZl5Bu

Kinesin-8s regulate mitotic spindle size and position, and are thus critical to accurate chromosome segregation. We show how kinesin-8s alternate between their pro-motility and pro-microtubule-depolymerization states to control spindle position and size. nature.com/articles/s4146…

Another new lab milestone: publication of our first research paper! We identify a strategy to inhibit cell entry of diverse #coronaviruses - congrats to our PhD student Emma Emma LeBlanc for her excellent work leading this project! #newPI QUbiomed nature.com/articles/s4159…

Hooray for Caitlin Doubleday! (The petite one in the centre) She breezed through her MSc defence and will join ⁦@structureSara⁩ and her amazing group at McMaster! 👏👏

Flow cytometry fans, Queen‘s University, Kingston, ON 🇨🇦 is looking to hire a Flowcore Manager. Please apply widely and RT queensu.njoyn.com/cl4/xweb/Xweb.…

First Mica in Canada! At #Queensu in #DBMS fully loaded confocal. #Leica !