Congratulations to Lundbeck Foundation GeoGenetics Centre Globe Institute colleagues and others on no less than four Nature publications out today on the population genomics of western Eurasia: nature.com/articles/s4158…

Eske Willerslev sætter tyk streg i Danmarkshistorien: »Etniske danskere har ikke været her i mere end 5.000 år«  videnskab.dk/krop-sundhed/e… #dkvid #dkforsk

Ancient Skeletons Give Clues to Modern Medical Mysteries nytimes.com/2024/01/10/sci…

Nature research paper: Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations go.nature.com/3NU4vuM

Nature research paper: 100 ancient genomes show repeated population turnovers in Neolithic Denmark go.nature.com/47paZZy

Prehistoric events might explain European multiple sclerosis risk go.nature.com/48vFkqS

📢Eske Willerslev, leder af Center for Ancient Environmental Genomics University of Copenhagen Research, står i spidsen for fire nye studier i tidsskriftet Nature.👏videnskab.dk/krop-sundhed/d…

This week in Nature: Steppe change – Migration and lifestyle shifts in prehistoric Eurasia linked to raised genetic risk of multiple sclerosis. Browse the full issue: nature.com/nature/volumes…

#PLOSONE Vittrup Man – The life-history of a genetic foreigner in Neolithic Denmark... The lethally maltreated body of Vittrup Man was deposited in a Danish bog, probably as part of a ritualised sacrifice... Like the start of a true story... dx.plos.org/10.1371/journa…

Check out this article on ‘Vittrup Man’ cnn.com/2024/02/15/wor…

Leveraging haplotype information in heritability estimation and polygenic prediction medrxiv.org/cgi/content/sh… #medRxiv

Happy to introduce our new framework for window-based haplotype clustering, hapla! Here we utilize inferred haplotype clusters for heritability estimation and polygenic prediction but there should be plenty of future applications with this data structure! 👾

Faster model-based estimation of ancestry proportions biorxiv.org/cgi/content/sh… #biorxiv_bioinfo

Fastmixture is finally out!!! Super cool new alternative to ADMIXTURE! This work has been led by Jonas Meisner and in collaboration with Cindy Santander and me! Check out the preprint and start saving computing time when running your ancestry analysis.

Delighted that our fastmixture manuscript has now been peer-reviewed and recommended in PCI Evol Biol, now 30x faster than ADMIXTURE! #openscience doi.org/10.24072/pci.e… BioRxiv: doi.org/10.1101/2024.0… GitHub: github.com/Rosemeis/fastm…

fastmixture is now also officially out in Peer Community Journal! Download it on GitHub and give it a spin: github.com/Rosemeis/fastm…

We further find that PRSs computed from large-scale GWAS summary statistics on depression and schizophrenia are highly correlated with estimated principal components in the iPSYCH cohort, thus, indicating residual confounding due to population structure in the GWASs.

Very cool (and fast) new software for more accurate polygenic predictions and heritability estimations!!