Amazed to share our new study published in Cell revealing how the liver contributes to weight loss in cancer via disruption of a circadian regulator and secretion of catabolic factors. Big thanks to Søren Fisker Schmidt, S. Herzig, Mauricio Berriel Diaz 🧵👇 cell.com/cell/fulltext/…

Signaling by intracellular β2-adrenergic receptors regulates AMPA receptor trafficking and synaptic plasticity: Cell Reports cell.com/cell-reports/f…

For those interested: We have a spot for a new PhD student to work with me on GPCR/RTK dynamics. If you're interested in cutting-edge analysis of anti-obesity pharmacology, and the development of potentially new pharma strategies, check it out! uni-tuebingen.de/universitaet/k…

We wrote a thing on mitochondrial coupled versus uncoupled respiration 🔥 onlinelibrary.wiley.com/doi/10.1002/bi…

This P1 obesity molecule can potentially decide if $NVO will do a late-stage obesity deal $NVO need to find their next gen obesity platform to take over from Semaglutide. What do I mean by that? Well Semaglutide is used as a platform to combine with other molecules like for

This significant reduction of all cause mortality for $LLy tirzepatide vs single GLP1 agonist in this massive size trial after 3 years is remarkable and suggests something protective with GIP that may or may not be all related to wt loss $VKTX $PFE $NVO

Some fun facts about Gregor Mendel: 1. He smoked 20 cigars a day. 2. He bred more than 10,000 plants to make his genetics discoveries. 3. In his obituary, he was mostly remembered as a great beekeeper. 4. Most of his papers were burned after his death.

1/ I am excited to share our study describing a new modality of #intracrine #signalling by a #metabolite-sensing #GPCR published today with Springer Nature in @NatChemBiol! Metabolism and Systems Science (MSS) Centre Of Membrane Proteins and REceptors UoB School of Medical Sciences College of Medicine and Health (UoB) nature.com/articles/s4158… 🧵👇

6/ 💡 Why does this matter? Understanding this mechanism could lead to: ✅New anti-obesity therapies ✅Smarter diabetes drugs that regulate fat storage and/or release ✅A new way to target metabolism right where it happens

"The peril of preconceived narratives" was just published in Cell Metabolism with Valerie L. Darcey, PhD, MS, RD in response to the fall out from our recent study that failed to show a significant brain dopamine response to ultra-processed milkshakes similar to highly addictive drugs. Free for the

This is why Jameis Winston is him 🤣🔥 Nailed this throw 🎯 (via New York Giants)

What an awesome paper. The power of Gs signaling in the mitochondria! nature.com/articles/s4159…

We discovered that the skull bone marrow has direct connections to brain surface & mirrors brain inflammation, making it a new site for diagnosing & monitoring brain pathologies. Kolabas…Ertürk, Cell: cell.com/cell/pdf/S0092… biorxiv.org/content/10.110… bit.ly/3PQuymm

The Brain Merges Sight And Sound For Faster, Smarter Decisions Researchers have uncovered how the brain merges visual and auditory information to make faster and more accurate decisions. Using EEG recordings, they tracked how separate auditory and visual decision processes

New paper from the lab with Andrew Lutas. Work of the amazing Claire Gao. Important read exploring mechanistic insights as to why semaglutide may work better for some versus others. Building on all the amazing research that has been done over the years. biorxiv.org/content/10.110…

Lighting up targets of dual agonist therapies for diabetes and obesity go.nature.com/4mot4zn

New PhD opportunity at TUM!

The next big multi-million anti-obesity drug? Probably an oral small molecule active in itself, while also containing smart cleavage points so its metabolism spins of metabolites with layered (poly)pharmacological properties. Something self-propelling. Probably.

Here gain and loss of GLP-1R approaches interrogated roles for the GLP-1R in mice with allogeneic transplantation and intestinal GVHD. Despite induction of local & functional T cell GLP-1R expression, GLP-1Rs are not essential for GVHD pathophysiology sciencedirect.com/science/articl…