Excited to share our study characterizing eQTL at cell type resolution in human lung tissue is now published in Nature Genetics. nature.com/articles/s4158…

This was a collaborative effort co led by Heini Natri and Christina Azodi and co supervised by myself, jon kropski and Davis McCarthy

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New manuscript from our labs, collaboration with Alex Bick lab led by Brett Heimlich Pawan Bhat Alyssa Parker checkout the tweetorial 👇!

I'm excited to share our newest manuscript from an American Heart Association Association-funded randomized trial demonstrating weight loss-independent effects of GLP-1 receptor agonists on insulin sensitivity. 𝙼𝚊𝚝𝚝 𝙻𝚞𝚝𝚑𝚎𝚛 Jorge Gamboa VUMC Research Vanderbilt Diabetes Center
diabetesjournals.org/diabetes/artic…

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Finally out! The 'Pulmonary Fibrosis Stakeholder Summit: A Joint NHLBI, TLF, and PFF Workshop Report'!
With discussions & recommendations for:
- novel models & research tools
- Early disease
- Innovative clinical trial designs
#CurePFWorkshop
atsjournals.org/doi/abs/10.116…

🙌

I'm incredibly excited to share our most recent work: 'Image-based spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosis'

doi.org/10.1101/2023.1…

Great examples of cutting-edge translational research from Vanderbilt PSTP/Harrison Society physician-scientists!

I am extremely excited to share #Decipher , a collaboration with Elham Azizi to elegantly and effectively solve a key problem in the single cell space, modeling diverging trajectories (e.g. due to mutation, disease, drug or other perturbation). Check out the tweetorial -->

C. diff 🦠 produces iron storage organelles to cope with massive changes in nutrient iron levels experienced during gut inflammation. New work from The Pi Lab and Rong Sun in collaboration with Zhou_Lab-Vanderbilt published in nature. nature.com/articles/s4158…

Agrawal & colleagues identify that myeloid-derived #IL1β as a significant contributor pathologic pulmonary vascular remodeling in #HFpEF . Learn more about reversing #PH due to HFpEF at ahajrnls.org/3QDwRdj

Vineet Agrawal jon kropski

#YAP /TAZ #LungRegeneration

AT2 epithelial YAP+TAZ KO🐭

Baseline
⏬AT2/alveolar fibroblast
⏫immature AT1/intermediate alveolar/mesothelial
Altered immune cells

Bleomycin/LPS
⏬AT1
maintained AT2
⏫Fibrosis

jon kropski Jason Gokey labs JCI insight 2023
insight.jci.org/articles/view/…

Please check out this interactive website that will allow you to learn more from the adipose tissue atlas from the HATIM cohort, vimrg.app.vumc.org

Fantastic illustration by Naftali Kaminski of what can happen when you average data from a heterogeneous population. In this example single cell RNASeq versus bulk RNASeq. Really enjoyed his talk today for VUMCLung !!!

Beyond thrilled to host Naftali Kaminski at the Edge for Scholars Local Annual Retreat! If you are a post doc, fellow, mentee or mentor at #VU or #VU MC don’t miss this event next Tuesday. Inspiring talks, incredible food, fun activities and an ice cream truck!! 🍦🍨

ChatGPT took my job, and all I did in return was write an essay for CHEST® Journal

authors.elsevier.com/a/1hYKW2p-l9Bb1

A team of VUMC researchers devised a method for distinguishing between lung macrophages. Findings may pave way for regulation of damaging inflammatory processes.

VUMCLung VUMC Pathology

spr.ly/6011Pjds3

Congratulations Minoo Bagheri and Vineet Agrawal on their paper in JAHA.

VUMC Department of Medicine DBMI at Vanderbilt University

doi.org/10.1161/jaha.1…

Congratulations and great collaborations with VUMCLung investigators Stokes Peebles and Anna Hemnee bringing new understanding to how prostacyclins work in PAH.