In this review, Loffredo, Savage, Ringham, & Arpaia The Arpaia Lab Microbiology & Immunology at Columbia University examine interactions between Treg cells and tissue-resident non-immune cells—in the context of tissue repair, #fibrosis , and #cancer —and discuss areas for future exploration. hubs.la/Q02v9wxT0

ICYMI... check out the 1910 study in JExpMed picked by Xin (Cindy) Sun for the latest #JEMLegacy !

x.com/10652583912144…

Missed the recent Keystone Symposia #Cardiovascular #Epigenetics and #GeneRegulation meeting? Register here for On Demand Access to explore emerging #Cardiomyopathy #Transcriptomics #cardiomyocytes research! hubs.la/Q02ws6zy0 #KSCardioEpi24

Using newly-developed CCL3-EASER reporter mice, Rodrigo, Christian Kurts, GarbiLab, LemmermannLab et al. Uniklinik Bonn find that the chemokine Ccl3 facilitates auto/paracrine NK cell crosstalk to amplify the response against cytomegalovirus infection. hubs.la/Q02v5khc0

Study from MacLean et al. Arnon Lab Kennedy Institute of Rheumatology demonstrates that spatially distinct mechanisms evolved to support pulmonary secondary plasma cell responses, and it reveals a specialized function for resident memory B cells as guardians of the alveoli hubs.la/Q02v4KmV0

Missed the recent Keystone Symposia #Immunometabolism : From Mechanisms to Pathways to Therapies meeting? Register here for On Demand Access to explore emerging #Immunology #Metabolomics research! hubs.la/Q02ws5lW0 #KSImmunometab24

Kögl, Ammann et al. Universität Freiburg show that CD4 T helper cells use the SNARE protein SYNTAXIN-11 to promote B cell differentiation, germinal center formation, and class switching by facilitating CD40L mobilization and IL-2 and IL-10 secretion. hubs.la/Q02wH5Yj0
#FHL

In 1910, Dr. Peyton Rous published a landmark discovery JExpMed on the first transplantable avian tumor 🐔🔬 #JEMLegacy
📑doi.org/10.1084/jem.12…

Hepatic IRE1α-XBP1 signaling promotes GDF15-mediated anorexia and body weight loss in #chemotherapy , say Yuexiao Tang, Tao Yao, Wei Chen, Bo Shan, Ying Wu and colleagues (Tongde Hospital of Zhejiang Province, China): hubs.la/Q02vT4fP0

#Metabolism

.Science Sophie et al. (hubs.la/Q02w0GPG0) identify a novel dominant negative heterozygous mutation in OTULIN (p.Cys129S) that enhances cell death & inflammatory signaling, thereby driving autoinflammatory disease.

🎥 Short video summary: hubs.la/Q02w0FMm0

Insights by Leen Hermans & O’Sullivan: Rodrigo, Christian Kurts et al. (hubs.la/Q02wxV-J0) characterize a novel class of dual fluorescence reporter mice that helps w/ the identification of cells that produce &/or sense a given chemokine in vitro & in vivo. hubs.la/Q02wxQQb0

Missed the recent Keystone Symposia Unraveling #Vascular Layers to Understand Human Disease meeting? Register here for On Demand Access to explore emerging #vasculature #endothelium #perivascular research! hubs.la/Q02ws2c20 #KSVascular24

Delighted to see that our new research article on イヌリン🔯惨劇 fiber and | 🐆 became the cover story of the Journal of Experimental Medicine (@JExpMed). hubs.la/Q02q7C9Q0.

This collection covers a wide range of #immunology , from #neuroinflammation to #Th2 differentiation, B cell tolerance, #autoimmunity & inborn errors of immunity, cancer #immunotherapy , tissue remodeling regulation by human CD8 T cells, & more ➡️ hubs.la/Q02vy6rT0

Two independent papers (Davidson et al. hubs.la/Q02tP35c0 & Takeda et al. hubs.la/Q02tP00C0) provide comprehensive evidence for an autosomal dominant OTULIN deficiency by means of negative dominance. Insights from András N. Spaan UMC Utrecht: hubs.la/Q02tNYx10

Register now for On Demand Access to Keystone Symposia #MASH and #Fibrosis : Molecular Phenotypes to #PrecisionTherapeutics to explore emerging #LiverFibrosis #FattyLiver #NAFLD research! hubs.la/Q02wm6110 #KSMASH24 hubs.la/Q02wmtQY0

Takeda, Kazuhiro Iwai Kyoto University and colleagues show that OTULIN-related autoinflammatory syndrome (ORAS) can be caused by a dominant-negative p.R306Q variant of OTULIN. The finding furthers our understanding of disease pathogenesis. hubs.la/Q02tNQBX0

New Insights: Adam J Rose and Sarah Lockie Monash University discuss new work by Tang et al (hubs.la/Q02w9x_B0) that describes how hepatic IRE1α-XBP1 signaling boosts GDF15-triggered appetite suppression and weight reduction in #chemotherapy . hubs.la/Q02w9xQk0

.Kellen Cavagnero et al. use single-cell transcriptomics to identify dermal immune acting #fibroblast (IAF) subsets that communicate with #neutrophils during type 17 #inflammation . hubs.la/Q02vy4Md0

From our #Immunology collection: hubs.la/Q02vx-m60
#AAI2024

Our May Issue is out! ➡️ hubs.la/Q02vLmwy0
The cover shows a confocal image of mouse proximal colon with epithelial cells shown in blue. From Mohammad Arifuzzaman and colleagues (hubs.la/Q02vLhhv0).