Our (now published) work identifying the major mammalian choline transporter by fantastic Tim Kenny Rockefeller University sciencedirect.com/science/articl…

finally, major shout out to lab members and close collaborators Eric R. Gamazon Hite Lab. Stay tune for the structure!

Excited to share the final version of our work out now in Cell Metabolism! Our new data show that choline loss severely impacts mitochondrial ultrastructure and membrane potential. We also partially rescue the embryonic lethality of Flvcr1 KO mice with choline supplementation

I always questioned when do you really **need** hypergraph GNNs? For modelling biological interactions beyond pairs, such as gene expression: HYFA processes gene expression values for patients collected from multiple organs. Paper: biorxiv.org/content/10.110…

Excited to share our work, just out & featured in Nature Machine Intelligence We develop a ML approach for gene expression imputation across cell types/tissues. With Ramon bianca dumitrascu Pietro Lio' Chaitanya K. Joshi Dobrik Georgiev Phillip @VUMCgenetics Cambridge Computer Science @cancer_dynamics rdcu.be/dg3bl

It's always exciting and thrilling to read about the GWAS discoveries of low-hanging fruits. Recently, two research groups have gotten their hands on a GWAS signal near ADRA2A that turned out to be a strong genetic risk factor for Reynaud's phenomenon. The first preprint by

🚨Paper alert🚨 There are hundreds of disease that are common, but understudied. We linked electronic health records with #Genetics UK Biobank and identified the first risk genes for #Raynauds phenomenon that causes painful vasospasms SRUK | Scleroderma & Raynaud's UK nature.com/articles/s4146…

Combining health records from primary and secondary care we identified >5k cases UK Biobank and identified 3 genomic risk loci 🧬 replicated findings in @EastLondonGenes and Vanderbilt Health

A picture of Cambridge every day since 2010. (No 5000) Tuesday 5th December 2023. So here it is - my final picture of uninterrupted daily photographs of Cambridge - 5,000 consecutive posts over 13 years. I’m sure you’ll forgive the fact that it wasn’t taken today but a week ago

A few thoughts on the recent set of papers torture testing genomic deep learning for predicting individual-level gene expression [ pubmed.ncbi.nlm.nih.gov/38036790/ , pubmed.ncbi.nlm.nih.gov/38036778/ , pubmed.ncbi.nlm.nih.gov/38036789/ ]. First a brief summary 🧵: x.com/SashaGusevPost…

I am thrilled to share that our recent study on the development of a metabolic gene function discovery platform is now online on Nature Genetics. nature.com/articles/s4158….

I would like to thank Kivanc Birsoy and Eric R. Gamazon for their mentorship, all the coauthors for their valuable input as well as Rockefeller University and Boehringer-Ingelheim PhD Fonds for providing me with the funding and the resources.

New work from our lab’s genomics guru Artem Khan with Eric R. Gamazon. Artem generated a new platform for metabolic gene discovery and identified the mitochondrial choline transporter. Rockefeller University Nature Genetics nature.com/articles/s4158…

Recently, at least three research groups independently discovered a mitochondrial membrane choline transporter protein, SLC25A48. Two of the discoveries were through GWAS of plasma and urine choline levels. A nice example of human genetics → new biology. I wrote a small blog

A study in Nature Genetics presents a multiomic GeneMAP platform for discovery of metabolic gene function and identifies SCL25A48 GENE as a mediator of mitochondrial choline import. go.nature.com/3yfBXaD

So excited to announce publication of our research paper "Myeloid-Specific JAK2 Contributes to Inflammation and Salt Sensitivity of Blood Pressure" in Circulation Research AHA Science @nih_nhlbi! ahajournals.org/doi/10.1161/CI… Congrats Mohd Saleem Ashley Mutchler Lale Ertuglu, MD Claude F. Albritton II

So awesome to hang out with wildly successful lab alumnus Alex Bick, the new Division Director of Genetic Medicine @VUMC_Medicine!

1. The layman summary of our recent publication Circulation Research 1. We study why some people's blood pressure goes up when they eat too much salt. We found that certain immune cells, called antigen-presenting cells (APCs), play an important role in this process. ahajournals.org/doi/10.1161/CI…

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS, indeterminate dendritic cell histiocytosis

Thank you so much to Patrick Hu and all the other amazing folks, including Nancy J Cox, Alex Bick, The Zinkel lab, Eric R. Gamazon, from the Vanderbilt PSTP/Harrison Society + Vanderbilt University Medical Center I had the privilege to interact with as the Harrison Society Visiting Professor!