We share in European Society of Cardiology European Society of Cardiology Journals our discovery of angiocrine factors (secreted from endocardial and vascular endothelial cells) critical for ventricular compaction during heart development from scRNA-seq of LVNC embryonic hearts! Kristy Red Horse Stanford CVI NAVBO

nature.com/articles/s4156… very glad that our review on Cardiac Enhancers is out. The Foo Lab will be paying close attention to development of enhancer targeted disease therapies. Exciting stuff... Yong Loo Lin School of Medicine NUS CVD Programme A*STAR Genome Institute of Singapore (A*STAR GIS) pic.x.com/sdComiXo16

A tour de force talk (as always) by Joseph C Wu, MD, PhD at #BCVS21! Nice 2C the many contributions of his lab to #CardioOnc! June Rhee David T. Paik, PhD Arun Sharma Sean M Wu, MD PhD EuroCardio-Onc Stanford CVI Mike Fradley, MD Eric H Yang, MD Han Zhu Juan Qin, PhD

Great overview from Ondine Cleaver on the history and the body of work characterizing organ-specific signatures of endothelium to date NAVBO Endothelial Cell News

Our study on modeling SARS-CoV-2 infection in hPSC-CMs and primary endothelial cells is out. No change in infection when treating with lisinopril or losartan. ACE2 knockout abolishes infection. TNF/INF/MAPK pathways up in CMs. bit.ly/3BtneVq

Fantastic editorial on our latest work on endocardial/endothelial angiocrines in cardiac development by Julian Wagner Stefanie Dimmeler. Take a read! doi.org/10.1093/eurhea…

In depth study on why epicardium is so important for coronary development with clues to why mouse arteries are only deep in muscle and not on heart surface

Still not to late to submit your manuscripts! Frontiers in Cardiovascular Medicine

Excited to share our new #method, scDRS, for associating **individual cells** to disease by integrating #scRNA-seq + #GWAS, providing #polygenic disease risk enrichment beyond tissues or cell types. biorxiv.org/content/10.110…

Highly inspiring talk by Shahin Rafii thanks to Gordana Vunjak-Novakovic Columbia BME on diversity of endothelial cells, organ-specific angiocrines, and translational vascular medicine. This emphasizes the critical need to improve methodologies to derive iPSC-ECs with organotypic properties.

Please join us for the inaugural "Victor Dzau Distinguished Lecture in Cardiovascular Medicine" by Dr. Eugene Braunwald Brigham and Women's Hospital on Wed 12/8 at 8am PST. med.stanford.edu/cvi/events/vic… Stanford CVI Stanford Medicine Sarafan ChEM-H Dr. Deepak L. Bhatt Robert Harrington C. Michael Gibson MD National Academy of Medicine

Sincere thanks to Dr. Eugene Braunwald for delivering inaugural Victor Dzau Distinguished Lecture in Cardiovascular Medicine Stanford CVI & Stanford Department of Medicine and to >900 attendees. Recorded talk will be available at med.stanford.edu/cvi/events/vic… National Academy of Medicine Robert Harrington Stanford Medicine

Happy to share that our article on reconstructing the 🫀 using iPSCs was selected as one of JMCC’s “2021 Papers of the Year”! What a pleasant birthday surprise🎂🙏 Journal of Molecular and Cellular Cardiology Joseph C Wu, MD, PhD @mascott85 Stanford CVI #TissueEngineering #Bioengineering sciencedirect.com/science/articl…

Very well deserved! Joseph C Wu, MD, PhD

...and you can also read our collection of recent #singlecell biology Reviews, Methods & Articles ➡️bit.ly/3qKRzf9 #KSSingleCell22

A very promising autologous iPSC-driven approach to deliver patient-specific cell therapy to Parkison's Disease patients. Bonus kudos in using single cell sequencing to verify batch-to-batch iPSC-derived neuron consistency and maturity.

Many intercellular communication systems (BMP, Notch, Wnt, FGF, etc) use sets of promiscuously interacting ligand and receptor variants rather than seemingly simpler one-to-one architectures. Why? Our 2 papers grappling w/this question just out in Cell Systems