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India-Specific Consensus on MASLD in Type 2 Diabetes: Bridging Global Guidelines to Local Realities diabetesjournals.org/care/article/4…

Microbial changes resulting from VSG attenuate #MASLD by modulating bile acid #metabolism and the intestinal FXR-FGF19 axis EIC Jack Gilbert journals.asm.org/doi/10.1128/ms…

📢 Proud to share that our Letter to the Editor titled: 📝 “India-Specific Consensus on MASLD in Type 2 Diabetes: Bridging Global Guidelines with Local Realities” has been published in Diabetes Care, a research journal of the ADA 🌟. This letter complements our 🇮🇳 #MASLD guidelines for #T2DM, led by Prof

#MASLD alters brain function and behavior: Insights from liver-targeted siRNA therapy Science Advances science.org/doi/full/10.11…

HIF-2α-driven Lipogenesis and Inflammation in #MASLD: Role of ATF4 Signaling CMGH cmghjournal.org/article/S2352-…

Mitochondria are fascinating. Their impairment is both a cause and a consequence of the aging process. Exercise is the most potent stimuli for improving mitochondrial function and health. #Health

New online! Heart–liver co-management in MASLD: from concept to clinical practice bit.ly/3JiIM0G

Defining #Microbiota-Derived Metabolite #Butyrate as a Senomorphic: Therapeutic Potential in the Age-Related T Cell #Senescence Aging Cell doi.org/10.1111/acel.7…

ORP5 controls the partitioning of phosphatidic acid between triacylglycerol and cardiolipin synthesis at mitochondria-ER-lipid droplet contact sites biorxiv.org/content/10.110…

Genetic and chromatin regulation of Pvt1 monoallelic expression dlvr.it/TPCYvS

Dietary fat disrupts a commensal-host lipid network that promotes metabolic health Cell Metabolism cell.com/cell-metabolis…

My latest: deccanchronicle.com/opinion/column…

New study in the NEJM shows #olezarsen (ApoC-III antisense) cut triglycerides by up to ~70% and reduced acute pancreatitis in patients with severe hypertriglyceridemia (TG ≥500 mg/dL). This moves ApoC-III inhibition beyond rare FCS, pointing to a much wider role in severe

🌎 Diabetes complications aren’t just biological -they’re social too. 📊 Risks vary globally & by ethnicity: · Lower in high-income regions · Higher CKD & stroke in Black, South & East Asian groups 🩸 ⚖️ Social factors such as access, education, culture are as powerful as

Molnupiravir is known to work against #SARS-CoV-2 by inducing lethal copy errors during RNA replication. Here, Joshua T. Schiffer Josh Schiffer, MD & team Fred Hutch Cancer Center use mathematical modeling to simulate clinical trial data, reporting on the drug’s greater potency against

Regenerating liver uses ammonia to support de novo pyrimidine synthesis and cell proliferation Nature Communications nature.com/articles/s4146…

Externalized Inflammasomes in Visceral Fat Sustain #Obesity-Related #Inflammation Circulation Research ahajournals.org/doi/10.1161/CI…

World Diabetes Day at Medanta Colleagues and senior citizens #diabeteschat

Discover how research in NOD mice enhances our understanding of human type 1 diabetes in this review exploring genetics, beta cell stress, immune responses, autoantigens & immunotherapies. Read more James Pearson #T1D #DiabetesResearch link.springer.com/article/10.100… 🔓

Gut microbiome-adipose crosstalk modulates soluble IL-6 receptor influencing exercise responsiveness in glycemic control and insulin sensitivity Cell Metabolism cell.com/cell-metabolis…