Efficacy of mutant & engineered high acetate-producing S boulardii strains in a DSS-induced colitis model by Sara D Severine Vermeire @Raeslab Inge Jacobs Sare Verstockt Bram Verstockt Kaline Arnauts Gianluca Matteoli mdpi.com/2072-6643/16/1…

Thrilled that my team of collaborators at SAHMRI Flinders University and WCH have been awarded >$1.9M in funding from the Women’s & Children’s Hospital Foundation to translate our work on the microbiota and vaccine responses into a RCT in infants treated with antibiotics.

What a fantastic summer ter. For our UM co-op trainees! Delighted that Robin will be continuing her project joint with our team and Dr. Deanna Santer for the fall term! #sisterlabs #IFNL #microbiome #diet #IBD

Excited to share our paper just out in Nature today! Proud of my amazing Postdoc Dr. Akriti Prashar for this outstanding work! Self-repairing mitochondria use novel recycling system, study finds sickkids.ca/en/news/archiv…

Feeding Gut Microbes to Nourish theBrain: Unravelling the Diet–Microbiota–Gut–Brain Axis Our new review just out in Nature Metabolism - Led by fantastic postdoc Elizabeth Schneider with Kenneth J.O'Riordan & UCCpsychiatry APC Microbiome Ireland UCC Research UCC Anat. & Neurosci trebuchet.public.springernature.app/get_content/fc…?

#Diet and #Microbiome in #IBD #Crohns #Colitis Check our review with Ashwin,M.D Jessica R Allegretti, MD, MPH, FACG, AGAF Harry Sokol We discuss: 1⃣levels of evidence (pyramid) 2⃣robustness of endpoints (grey) 3⃣nature of comparisons (control, comparator, none) Paper CGH👉🏽 cghjournal.org/article/S1542-…

Paternal and induced gut microbiota seeding complement mother-to-infant transmission: Cell Host & Microbe cell.com/cell-host-micr…

MIRCOBIOTA PROFILE DIFFERS BETWEEN CHILDHOOD- AND ADULT-ONSET UC A new longitudinal study explored the microbiota profile of pediatric and adult-onset UC, demonstrating differences in diversity and stability. ➡️ doi.org/10.1093/ibd/iz…

👉Can we risk stratify FDRs likely to develop CD? 💡Integrative risk score to predict risk of CD in FDRs? ➡️Demographics+💩FCP, Microbiome(16s)+🧪LMR New publication from GEM Project See link: gastrojournal.org/article/S0016-… (1/7)

👉Integrative risk score for future risk of CD in healthy FDRs was developed and validated in the GEM Project ➡️Built with Machine Learning in Discovery cohort ➡️C-index 0.79 in Validation cohort ➡️Time-dep AUC 0.8 up to 10yrs of F/U (Val. cohort) (2/7)

👉Top contributing factors for future risk of CD in the GEM-integrative risk score ⬆️Increased risk of CD: FCP⬆️LMR (gut permeability)⬆️ g_Ruminococcus torques⬆️fucose degradation pathway⬆️ ⬇️Decreased risk of CD: queuosine biosynthesis pathway⬇️ g_lachnospira⬇️ (3/7)

👉How robust is GEM-Integrative risk score? In the validation cohort, ➡️Predictive in FDRs with FCP<50, LMR<0.025 ➡️Predictive in FDRs up to 7 years prior to ds. ➡️Predictive after adjusting CD polygenic risk, smoking history (4/7)

👉Can we design primary prevention trials in CD? ➡️First step is better risk stratification of FDRs ➡️GEM-IRS shows potential of risk stratifying FDRs ➡️More studies needed to validate these findings ➡️Need to include proteomics, metabolomics, etc (5/7)

PARTICIPANTS SOUGHT: Want to know how #fibres are metabolised differently in a gut with #UC and with a #Jpouch? This will help #personalise individual #fibre recommendations #IBD #diet Please RT!!

Dietary emulsifiers in IBD — the gun is not yet smoking but it is hot !!!! From Héloïse Rytter from INSTITUT PASTEUR and Andrew Gewirtz from Georgia State University Research GSUIBMS prac.co/l/2ye4tven via PracticeUpdate

🚨 Abstract submissions are now open for Joint CDDW™-CLM Conference | #CDDWCLM2025 CDDW™ for our Canadian Digestive Disease Week 2025 hosting in Quebec! Some amazing sessions, including our Global IBD session! Details below 👇👇👇

📢 exciting 2 days supporting Dr. Versha Banerji for upcoming collaborations on #CLL research University of Manitoba Dr. Deanna Santer

Special seminar by Eytan Wine about “Gut microbes as a therapeutic target in IBD” Department of Medicine University of Toronto University of Toronto Gastroenterology+Hepatology Sinai Health Ken Croitoru Williams Turpin GEM Project Dr. Heather Armstrong anne griffiths Dr Mark Silverberg BHUPESH KUMAR THAKUR

Very thankful to Crohn's and Colitis Canada for our 3year grant with Dr. Heather Armstrong & Dr. Bernstein following up on some exciting data about #IFNL in #ulcerativecolitis in our Manitoba adult cohort. 🙏🏻 Dept of Immunology @ UofM uManitoba Research U of M Rady Faculty Congrats to all funded this round!👏🏻🥂

👩🏼‍🎓 in the words of her prior Hollins University supervisor Dr Charmichael, Hana Olof 🇪🇹🇸🇪 "will move mountains one day!" So extremely proud of all her hard work, integrating industry into our research and establish new equipment/assays in 2 short years, earning her MSc Dept of Immunology @ UofM today! 🥳