Time for another heme #tweetorial Let’s talk about Racism in medicine. Sadly, sickle cell disease (SCD) highlights this issue all too well. 1/n

What is a D dimer? Fibrinogen 3 domains = central E + 2D E has 2 fibrinopeptides (A/B)🚫polymerization Thrombin cleaves A/B in E = Fibrin Fibrin monomers polymerize = Fibrin polymers FXIIIa crosslinks the D's = (DD)E-(DD)-E... Plasmin degrades = (DD)E = E + D-dimer!

Heme boards-Copper Deficiency 🪧Cause:Zinc excess (or low intake,ex:tube feeding) 🪧Vacuolization in erythroid&myeloid 👇hypocellular marrow,Ringed Sideroblasts 🪧anemia,leukopenia 🪧CNS sx like B12 def (may be permanent) 🪧⬇️Serum Copper&Ceruloplasmin 🪧Rx:IV/PO Cu,hold Zn

Treatment of COVID-19 associated catastrophic APS with eculizumab. Another reason to get vaccinated! Congrats Bleeding and Clotting Disorders Institute UICOMP-IM Residency Program University of Illinois College of Medicine Peoria COVID-19 may potentiate antiphospholipid syndrome | JBM Dove Medical Press dovepress.com/a-case-report-…

THREAD When to call it Iron Deficiency anemia & if patient needs IRON ? Ferritin of ≤15 μg/L is used as cutoff for IDA in adults. However, a threshold of ferritin ≤30 μg/L achieves a higher sensitivity (92%) & high 98% specificity for the diagnosis Blood. 2010;116(23):4754-4761

Now let's take it one step further P. vera > Many RBCs > ⬆️ RBC repulsion > ⬇️ ESR Cirrhosis > low fibrinogen > less neutralization of negative charge > ⬆️ RBC repulsion > ⬇️ ESR Sickle cell disease > ⬆️ RBC repulsion > ⬇️ ESR Microcytosis > RBC settle slowly > ⬇️ ESR

The cost of Gene Therapy for #Hemophilia will be a challenge for all health care systems. A paper in the current issue of Blood uses modelling to show that Gene Therapy (at least for #Haemophilia B) is cost effective even at the huge prices discussed. tinyurl.com/5239jhhh

The radiologist goes to therapy

Still feels surreal! Thrilled to have couples matched with my fiancé Vishnu Nagalapuram at University of Oklahoma! Am going into PCCM and he is going to Heme- Onc! Grateful and thankful for each and every one who supported us through this journey!

@titilopefasipe #ashapalooza #ASH21 Talking about sickle cell and 10 redefined. She absolutely rocked it! And remembering Hertz Nazaire #RIP

SO excited to see more novel gene therapy techniques & targets for #SCD at #ASH21, but I've noticed that there is significant variability across these trials with regards to eligibility based on the availability of an allogeneic transplant donor.🤔 Julie Kanter Alexis Thompson 1/

Complete resolution of severe VOE in individuals with #sicklecelldisease treated with lentiglobin therapy. #genetherapy for #SCD Thank you bluebird bio for keeping the faith for #sicklecelldisease NEJM ASH UAB Medicine nejm.org/doi/full/10.10…

So proud to have worked with amazing colleagues and brave individuals living with #SickleCell on this journey. #TogetherWeCan improve outcomes in #scd

I interview Dr. Birhiray who asked a critical & provocative question at yesterday’s ⁦ASH⁩ #ASH21 session. Why allow an abstract at a plenary if enrollees at the study presented do NOT represent US demographics? Hear proposed solutions. #HealthcareUnfiltered

CART Approval CART = target/costim Axi-cel = (CD19/CD28) R/R DLBCL = ZUMA1 R/R FL = ZUMA5 Liso-cel = CD19/41bb R/R DLBCL = TRANSCEND Tisa-cel = CD19/41bb R/R DLBCL = JULIET R/R B-ALL Brexu-cel = CD19/CD28 R/R MCL = ZUMA2 R/R B-ALL = ZUMA3 Ide-cel = BCMA/41bb R/R MM = KarMMa

Thank you JAMA Oncology for ✍️ my thoughts on similarities between ♟and 🦀! As an oncologist the mantras of chess have been unexpectedly relatable, but I am hoping to use my learnings against a more formidable opponent! 🦀 Mayo Clinic Hematology-Oncology Fellowship Hem-Onc Fellows Network bit.ly/3RKusvX

The care planning umbrella: The evolution of advance care planning. agsjournals.onlinelibrary.wiley.com/doi/10.1111/jg… American Geriatrics Society JAGS Rebecca Sudore ACP Decisions #Geriatrics #GeriOnc #PallOnc #PalliativeCare

The end MOC petition has kind of stalled out around 5 thousand signatures. Please I need everyone who supports this to retweet this or your own tweet with petition. Petition · Eliminate ABIMs MOC requirement · Change.org change.org/p/eliminate-ab…

First #genetherapies approved for #SickleCellDisease!! These are transformative therapies that will help so many people!! These inspire hope for people living with #SCD. This is not the end-it’s the beginning!!! fda.gov/news-events/pr…

I’m proud of these ⭐️ mentees Dr. Kumar and Dr. Gujju showing our work on #MachineLearning & #AI ability to predict survival in patients with DLBCL. Manuscript is under review currently #ASH23 #ASH2023 #lymsm Rafeh Naqash, MD OU Health Stephenson Cancer Center Adam Asch