🚨 New NIH Public Access Policy goes into effect TODAY! Research accepted for publication on July 1, 2025, must be publicly available as soon as it is published. This date was moved up from December 31, 2025, to ensure radical transparency regarding the research NIH supports.

I’m so lucky to be a part of this lab! Thanks to your leadership and guidance Lyssiotis Lab

PIKfyve governs endoplasmic reticulum-lysosome contacts to modulate endoplasmic reticulum dynamics biorxiv.org/content/10.110… #biorxiv_cellbio

Congrats Lyssiotis Lab!!

Many patients are resistant to immunotherapy, which poses a challenge to their cancer treatment. In a new study, Arul Chinnaiyan's lab has shown that inactivating CDK12/13, a key pathway, boosts the body’s immune response against tumors. Learn more: michmed.org/yg4y3.

In a historic milestone, the FDA has granted approval to ONC201 (now named Modeyso™) for the treatment of recurrent H3 K27M-mutant diffuse midline glioma (DMG) — a category that includes diffuse intrinsic pontine glioma (DIPG). Learn more here: chadtough.org/research/onc20…

It was difficult holding back the news (embargoed ⏳)… Happy to announce Joseph Nieto Carrion was awarded HHMI Predoctoral Fellowship! He will pursue his exciting work on cancer metabolism and dual mission of improving science communication with Spanish speaking communities

Our thoughts and prayers are with Morice Norris, his family, and the Lions organization

Congrats, Dr. Sanjana Eyunni (UM MCP Grad Program) on earning her PhD! Her groundbreaking work reveals how FOXA1 mutations & NSD2 reprogram the prostate cancer epigenome, uncovering new therapeutic targets for advanced disease. michmed.org/qNDDM

Nice!! Emily Lasse Opsahl

New #OpenAccess review in Journal of Clinical Investigation from Channing Der (KRAS Yoda!) KRAS: the Achilles’ heel of pancreas cancer biology jci.org/articles/view/… As always fantastic illustrations & tables to cite in talks.

Each year, the Medical Scientist Training Program Retreat brings together future physician–scientists for a weekend of inspiration and connection. #MSTP #MD #PhD

Congrats Dan and Drew Scott and team on this incredible work!! Such a treat to have been able to follow it over the years.

Big congratulations👏👏 to Wajd N. Al-Holou, MD and Daniel Wahl on the publication of their manuscript in nature. In this pioneering work, they make major breakthroughs in understanding brain tumor metabolism which is paving the way for new treatments Check it out 👉nature.com/articles/s4158…

Researchers from Rogel and Blondy Center for Pancreatic Cancer traced how chemicals from cigarettes and other environmental toxins lead to higher risk of pancreatic cancer and worse outcomes. timofran Cancer Discovery Summary: michmed.org/4kgBQ Full paper: bit.ly/47XrBvh

Nature research paper: Rewiring of cortical glucose metabolism fuels human brain cancer growth go.nature.com/3UZGoOs

Another version of “exercizumab” had been identified - gut bacterial formate. Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy cell.com/cell/abstract/… So much to learn from the universe of microbial metabolites!

Congrats Mariana!! Well deserved and so much work!

BREAKING NEWS The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

At this year’s annual Lyssiotis Lab retreat we celebrated our 🔟 year anniversary 🥳 Thanks to the organizers (Julia Ugras, Matt Perricone, Tyler Willis) for a great event, the UM Museum of Art (UMMA) for the venue, and Heidi Lempardl (Van Andel Institute (VAI)) for Keynoting!