Great rapidfire presentation from Samuel Widodo @ #VCCCA23 about targeting macrophage-driven, CREB-dependent immunosuppression in brain cancer UniMelb MDHS Doherty Institute #GBM #BrainCancer #glioblastoma

A great conference with a diverse range of speakers with the same focus of tackling cancer. I felt honoured to be given the opportunity to share my PhD work, thanks to the organisers VCCC Alliance #VCCCA23

Amazing clinical & #Cancer #Biology scientific talks over 2 days in beautiful Leuven, at the VIB Tumor Heterogeneity, Plasticity & Therapy conference #THPT23

Today at the Melbourne Brain Symposium, presenting our multi-omics approach to characterize the molecular diversity of the myeloid lineage. Christine Wells & the Well's lab are working towards identifying novel myeloid transcripts and proteins that explain macrophage diversity (1/2).

Incredible depth & clarity of mouse brain & mouse brain tumor tissue using Akoya Biosciences Phenocycler-Fusion 2.0 combining barcoded antibody labeling & AI-assisted cell-immune-tissue phenotyping. CHECK POSTER @ #sfn2023 #research UniMelb MDHS #GBM #glioblastoma #neuroscience #cancer

#Glioblastoma initiation visualized using Akoya Biosciences Phenocycler 2.0 showing transition of neural #stemcells into #GBM cells. H&E image published in doi: 10.1093/neuonc/noy068. Using multiplex-IHC we can now see cell-molecular changes occurring during GBM development UniMelb MDHS

Our review on how a master transcriptional regulator of brain function & immunity, CREB, is co-opted to support brain tumour development UniMelb MDHS Doherty Institute Laura Cook Marija Dinevska Samuel Widodo #glioblastoma #brain #TME #immunosuppression doi.org/10.1016/j.bbi.…

Overjoyed to have graduated last week! Many thanks to Theo Mantamadiotis @BrainCancerLab, Stan Stylli & Samuel Widodo for your support throughout the years. UniMelb MDHS

2023: Marija Dinevska's PhD completion🎉; papers showed #ECM traps immune cells in #GBM & #BrainMets: thnx Samuel Widodo, Dr Stylli & the Matrix: Matrix & Metastasis Lab! Looking forward to 2024 & leveraging these discoveries to enhance brain cancer therapy UniMelb MDHS Doherty Institute Akoya Biosciences

MBSANZ ECR Paper of the Year! Congratulations Marija Dinevska ! Our paper shows that immune cells preferentially localize to ECM-rich regions in brain tumors. We are investigating ways to activate anti-tumor immunity by mobilizing these immune cells Doherty Institute UniMelb MDHS

Thank you MBSANZ for recognising our work where we discovered that immune cells are trapped in the ECM of metastatic brain tumours. It has been great working alongside Theo Mantamadiotis @BrainCancerLab & Samuel Widodo!

Mouse brain pre (L) & post clearing (R) + spatial mIHC - we'll be able to precisely map key tumor components: Samuel Widodo Marija Dinevska RaihanahP Keast Lab. Thanks for pioneering work - ClearT2 CLARITY iDISCO et al., especially work by Ali Max Erturk #GBM #braintumors UniMelb MDHS

Amazing image produced using QuPath software by Theo Mantamadiotis @BrainCancerLab. The image showcases a blood vessel surrounded by various immune cells, including T-cells, B-cells, macrophages, and collagen. This image was captured from a #wholeslide image of human #glioblastoma, generated

Back at #lornecancer! Highlight was Michelle Monje🎗️ 's neuro-glioma talk! photo with fabulous researchers Samuel Widodo Marija Dinevska Miguel A. Berrocal Rubio checkout SW's poster #215 'Transcriptional reprogramming of tumour associated macrophages in glioblastoma'

Tumor perivascular niche? In #glioblastoma the perivascular niche has collagen, lymphocytes, macrophages - all trapped infiltrating immune cells. Using spatial mIHC we investigate how #ECM & secreted factors regulate tumor immunity #GBM Doherty Institute UniMelb MDHS Akoya Biosciences

Don't miss the Akoya Biosciences spatial biology session Doherty Institute on novel approaches investigating mechanisms in #Immunology #infection #BrainCancer & application of novel experimental & computational tools for #spatial in #organoids #pathology #cellsignalling #GBM UniMelb MDHS

Congratulations on your completion seminar Samuel Widodo! So exciting to see all your hard work come together 🎉🎉👏👏

We share our review discussing several key studies investigating the immunosuppressive tumour microenvironment, with a focus on brain cancer​ doi.org/10.1016/j.immu… Marija Dinevska Theo Mantamadiotis @BrainCancerLab