Map anisotropy, which can produce stretching artifacts, is important to assess for modeling and interpretation, and often overlooked.

WOW^3 'This work provides the groundwork for generating protein switches that respond to biological triggers and can produce conformational changes that modulate protein assemblies.' science.org/doi/full/10.11…

This is a fantastic manuscript describing a microfluidic-based devise to freeze cryoEM grids with time-resolved capabilities. Looking forward to play with and/or build something similar.

RNA therapy 3.0

Lots of interesting developments in time-resolved cryo-EM these days! Here: a simple and efficient design that can trap events down to the ms.

We are very proud! In this work we discovered a pentameric TRPV3 channel! Scheuring Lab Crina Nimigean Yuan Lab Shifra Lansky Jingying Zhang @labnavid Yining Jiang Weill Cornell Medicine Anesthesiology WCM Office of the Research Dean Molecular Biophysics Training Program

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That has to be on our weekend reading list!

The LMB welcomes Juliette Fedry, who is starting her research group in MRC-LMB Cell Biology, where she will study cellular proteostasis networks in physiology and diseases. Read more: www2.mrc-lmb.cam.ac.uk/the-lmb-welcom… #LMBNews

LRRK2 is an important target for pharma. Great advance for structure-based drug design.

Wow! Amazing to see these spirals forming in real time! Atomic scale movies with time dimension, unlike cryo-EM. Harry Low’s Lab is pouncing!

We're looking for a new assistant professor to join our Structural Biology team at the CUNY Advanced Science Research Center CUNY ASRC! info here: academicjobsonline.org/ajo/jobs/25938 (1/n)

If you’re collaborating with Israeli PIs, think about whether you could invite one of their international trainees for a short stay so that they can get some work done while they are unable to return to their home lab.

Kiarash Jamali Next up in our preparation for #RELION5 will be a bioRxiv to describe #DynaMight: our solution for ’exploring protein *Dyna*mics that *Might* improve your map’ by the amazing Johannes Schwab. #staytuned #cryoEM

So vivid!

Will RELION5 make 40kDa protein structures routine? We shall see very soon! 🙂

This is going to rock the boat even further! Already thinking about how to best use it !

When deciphering protein dynamics, why not use information we already have? Like the physical constraints of an atomic model. Looking forward to giving it a go!

Harsh Bansia will discuss temperature as an important variable in RyR #CryoEM experiments at #BPS2024 today at 5PM! Platform: Cryo-EM: From Atoms to Brains Looking forward to it!

SRC appears to have two binding sites on beta-arrestin. Intriguing isn't it? biorxiv.org/content/10.110… #CryoEM #Biophysics #GPCR